Pharmaceutical composition of emetine hydrochloride and application of pharmaceutical composition in biomedicine

A technology of emetine hydrochloride and composition, applied to pharmaceutical composition and its application field in biomedicine, can solve the problems such as the correlation report of emetine hydrochloride and its pharmaceutical composition, etc., which can improve lung immunity. Function, pulmonary immune function improvement, improvement effect improvement effect

Inactive Publication Date: 2016-07-20
薛丽云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between emetine hydrochloride and its pharmaceutical composition and the improvement of lung immune function

Method used

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  • Pharmaceutical composition of emetine hydrochloride and application of pharmaceutical composition in biomedicine
  • Pharmaceutical composition of emetine hydrochloride and application of pharmaceutical composition in biomedicine
  • Pharmaceutical composition of emetine hydrochloride and application of pharmaceutical composition in biomedicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0020] Separation method: (a) Grind Codonopsis pilosula (3kg), extract with 75% ethanol under hot reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and then use petroleum ether (4L×3 times) , ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use AB-8 type macroporous resin to remove impurities from the n-butanol extract, first elute with 6% ethanol for 8 column volumes, then use 70% ethanol for 8 column volumes, collect 70% eluate, and concentrate under reduced pressure Obtain 70% ethanol elution concentrate; (c) in step (b), 70% ethanol elution concentrate is separated with normal phase silica gel, is 50:1 (8 column volumes), 25:1 (8 column volumes) successively with volume ratio column volume), 15:1 (8 column volumes) ...

Embodiment 2

[0023] Embodiment 2: pharmacological action

[0024] In this example, compound (I), emetine hydrochloride, and the combination of emetine hydrochloride and compound (I) were studied to improve lung immune function.

[0025] 1. Materials and methods

[0026] 1.1 Reagents

[0027] Emetine hydrochloride was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Pentobarbital sodium; RPMI1640 (WithL-glutamine; Withoutsodiumbicarbonate), GIBCOBRL company; Mycoplasma-free newborn calf serum (NewBornCalfSerum), Hyclone company; Hepes, Sigma company; LDH kit, ACP kit, Nanjing Jiancheng Institute of Bioengineering ; Hydrobromoornithine; India Ink.

[0028] 1.2 Experimental Instruments

[0029] 752 ultraviolet spectrophotometer, Shanghai No. 3 Analytical Instrument Factory; water-proof electric heating constant temperature incubator, Chongqing Sida Experimental I...

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PUM

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Abstract

The invention discloses a pharmaceutical composition of emetine hydrochloride and application of the pharmaceutical composition in biomedicine. The pharmaceutical composition comprises the emetine hydrochloride and a natural product compound (I) of a novel structure; when in single action, the emetine hydrochloride and the natural product compound can enhance the pulmonary macrophage phagocytosis function and AMphi activity, and play a role in improvement of the pulmonary immunization function; when the emetine hydrochloride and the natural product compound are in combined action, the improvement effect in the pulmonary immunization function is further improved, and the pharmaceutical composition can be developed into drugs for improving the pulmonary immunization function; compared with the prior art, the pharmaceutical composition has outstanding substantial characteristics and significant improvement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of emetine hydrochloride, in particular to a pharmaceutical composition of emetine hydrochloride and its application in biomedicine. Background technique [0002] Emetine hydrochloride can interfere with the division and reproduction of histolytic amoeba trophozoites, so it can kill them. For patients with acute amoebic dysentery who urgently need to control symptoms. It is also effective in treating extraintestinal amoebiasis such as amebic abscess of liver, lung, brain and kidney. In addition, it can also be used for scorpion stings and paragonimiasis. [0003] So far, there has been no report on the correlation between emetine hydrochloride and its pharmaceutical composition and the improvement of lung immune function. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of emetine hydrochloride, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/58A61K31/4725A61K31/352A61P37/02A61P11/00
CPCC07D311/58A61K31/352A61K31/4725
Inventor 薛丽云
Owner 薛丽云
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