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Dragon's blood jelly spray for treating pressure sores and its inspection and preparation method

An inspection method and spray technology, which can be used in aerosol delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. inconvenience etc.

Active Publication Date: 2019-07-26
中国医学科学院药用植物研究所云南分所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This way of use is easy to contaminate clothing, bed sheets, etc. during the treatment process, resulting in the loss of drugs; the use of medical dressings in the dressing will cause inconvenience to the patient's movement, and cause secondary damage to the wound when changing the drug
In addition to the above disadvantages, dragon's blood is insoluble in water, and its low bioavailability is also an important limitation affecting its use

Method used

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  • Dragon's blood jelly spray for treating pressure sores and its inspection and preparation method
  • Dragon's blood jelly spray for treating pressure sores and its inspection and preparation method
  • Dragon's blood jelly spray for treating pressure sores and its inspection and preparation method

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preparation example Construction

[0056] The preparation method of the Dragon's Blood Spray involved in the third aspect of the present invention comprises:

[0057] Step B, using ethanol as a solvent to prepare dragon's blood solution and film-forming agent solution respectively;

[0058] Step C, slowly adding the dragon's blood solution to the film-forming agent solution according to a certain volume ratio, shaking, and mixing evenly to prepare the dragon's blood spray precursor mixture;

[0059] Step D, drop distilled water into the dragon's blood spray precursor mixture while stirring, and make the dragon's blood spray after mixing.

[0060] According to the present invention, in the precursor mixture of the dragon's blood spray, the volume ratio of the dragon's blood solution to the film-forming agent solution is (1-3):1, preferably the dragon's blood solution and the film-forming agent The volume ratio of the solution is 1:1.

[0061] In some embodiments of the present invention, the concentration of t...

Embodiment 1

[0069] Example 1: Optimization of the preparation process of Dragon's Blood Spray.

[0070] In order to confirm the optimal proportioning ratio of Dragon's Blood Spray, the inventor designed an orthogonal experiment to optimize the preparation process of Dragon's Blood Spray. The factor levels of the orthogonal experiment are shown in Table 1, and the results of the orthogonal experiment are shown in Table 2. The analysis results are shown in Table 3.

[0071] Table 1 Factor level table

[0072]

[0073] Table 2 Orthogonal table of film spray preparation process

[0074]

[0075]

[0076] It can be seen from Table 2 that the order of factors affecting the film-forming time and viscosity of Dragon's Blood Membrane Spray is as follows: C>A>B, and item D is a blank item.

[0077] The variance analysis table of table 3 preparation process

[0078] source of variance SS f F P A 20816.67 2 19.42 <0.05

B 2985.5 2 2.78 >0.05 C 23035.92...

Embodiment 2

[0087] In order to control the quality of Dragon's Blood Membrane Spray, the inventor drew the fingerprint of Dragon's Blood Membrane Spray by comparing the similarity peaks of 10 batches of Dragon's Blood Membrane Spray, see figure 1 . The experimental conditions are as follows:

[0088] Instruments and Reagents

[0089] The high performance liquid chromatograph model is: UPLC (Waters Aquity H-Class, PDA detector); Electronic balance (METTLER TOLEDO, model: AB265-S); Chlorhexidine digfluconate (sigma company, batch number: LRAA1627, specification: 1g / mL) ; Dragon Blood B (National Institute for Food and Drug Control, batch number: 111558-201407); Ethanol (Beijing Chemical Plant, batch number: 20150504); Acetonitrile (Fisher Scientific, batch number: 134145); Triethylamine (Sinopharm Chemical Reagent Co., Ltd. company, batch number: 20131104); phosphoric acid (Tianjin Guangfu Technology Development Co., Ltd., batch number: 20120403).

[0090] Chromatographic conditions: UPL...

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Abstract

The invention relates to a dragon's blood spray for treating pressure sores as well as a preparation method of the dragon's blood spray. The dragon's blood spray consists of a dragon's blood extract, polyvinylpyrrolidone K30 which serves as a film-forming agent, ethanol, water and the like. The preparation (the spray) is simple in dosage, convenient to use and high in bioavailability, and the preparation has an obvious treatment effect on the pressure sores. The invention relates to a detection method of the dragon's blood spray for treating the pressure sores. The method is simple and convenient and is relatively good in operability, and the quality of the dragon's blood spray for treating the pressure sores can be accurately detected and controlled.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a dragon's blood spray for treating pressure sores and a testing and preparation method thereof. Background technique [0002] Dracaena dracaena is a resinous component produced by the sword-leaf dracaena under the influence of certain factors, and it has a definite astringent and muscle-promoting effect. Among the muscle-promoting prescriptions recorded in ancient books such as "Liu Juanzi Gui Yi Fang" and "Yi Zong Jin Jian" for treating ulcerative wounds, dragon's blood jerky is the most frequently used. In modern clinical practice, dragon's blood is often used for ulcers caused by various diseases. The combination of dragon's blood with other antibacterial drugs or physical therapy can greatly improve the cure rate of pressure sores. However, the application of dragon's blood in clinical treatment and nursing is relatively primiti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K36/896A61P17/02G01N30/02
CPCA61K9/7015A61K31/045A61K36/61A61K36/896A61K47/32G01N30/02G01N2030/027A61K2300/00
Inventor 李宜航
Owner 中国医学科学院药用植物研究所云南分所
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