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Microfluidic system achieving disease diagnosis through active tiny organisms and diagnosis method of microfluidic system

A technology for microfluidic systems, diagnostic methods, and applications in biochemical equipment and methods, enzymology/microbiology devices, specific-purpose bioreactors/fermenters, etc.

Inactive Publication Date: 2016-11-23
李木
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the problem in the field of application is: in the above-mentioned diagnostic process, how to accurately and quickly control the active micro organisms with a size of less than 1 mm, down to the micron level?

Method used

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  • Microfluidic system achieving disease diagnosis through active tiny organisms and diagnosis method of microfluidic system
  • Microfluidic system achieving disease diagnosis through active tiny organisms and diagnosis method of microfluidic system
  • Microfluidic system achieving disease diagnosis through active tiny organisms and diagnosis method of microfluidic system

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Embodiment 1

[0058] A typical embodiment of the present invention is Figure 1 ~ Figure 3 shown.

[0059] The schematic diagram of the system structure of Embodiment 1 of the present invention is as follows figure 1 As shown, it includes the control part, the sensing part, the microfluidic chip, the active micro organism and other parts, and the active micro organism is located inside the microfluidic chip.

[0060] The control part is the control center of the whole system, responsible for the tasks of data reception, calculation, processing and other links.

[0061] The sensing part senses, measures, collects, ingests, records, judges, converts, and transmits experimental phenomena and signals that occur inside or on the surface of the microfluidic chip.

[0062] The microfluidic chip in this embodiment is a specific type of the liquid carrier of the present invention. The microfluidic chip contains a plurality of electrodes, and all or part of the electrodes can be cut into or disconn...

Embodiment 2

[0066] A typical embodiment of the present invention is figure 1 , figure 2 , Figure 4 shown.

[0067] The system structural diagram, control logic diagram and corresponding description of Embodiment 2 of the present invention are the same as Embodiment 1.

[0068] The schematic diagram of the diagnostic method of embodiment 2 of the present invention is as Figure 4 As shown, the present embodiment uses comparison droplets, and the comparison droplets are selected as pure water droplets; and fluorescently labeled nematodes are used as the type of active micro organisms, the disease type is selected as cancer, and the test sample is a human urine sample .

[0069] The diagnostic method of Example 2 of the present invention is: through the driving and control of the control part, the nematode-encapsulated droplet is placed between the test sample and the pure water droplet inside or on the surface of the microfluidic chip, and the nematode droplet Close to the other two ...

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Abstract

The invention relates to a microfluidic system for disease diagnosis, in particular to a microfluidic system achieving disease diagnosis through active tiny organisms and a diagnosis method of the microfluidic system. The microfluidic system comprises a control part, a sensing part, a microfluidic chip and the active tiny organisms, and reactions of the active tiny organisms on test samples whether containing components, odors or phenomena related to a disease or not have difference phenomena or results. The diagnosis method comprises the steps that liquid drops wrapping the active tiny organisms are put near the test samples through driving of the control part inside or on the surface of the microfluidic chip, the liquid drops and the test samples are controlled to be close to each other, displacement of several time or changes of other characteristics and parameters of the tiny organisms in the process and before and after the process are obtained through the sensing part, and therefore whether the test samples have matter or odors or phenomena related to the above-mentioned disease or not is deduced.

Description

technical field [0001] The invention relates to a microfluidic control system and a diagnostic method thereof, in particular to a microfluidic control system and a diagnostic method thereof for realizing disease diagnosis by using active tiny organisms. Background technique [0002] Today, the evolution of germs and the mutation of viruses are becoming more and more rampant. Many diseases cannot be cured quickly and effectively, such as cancer, cardiovascular and cerebrovascular diseases, etc. In the field of diagnosis and treatment, especially the detection and diagnosis of early diseases are of great importance to human health. significance. Taking cancer as an example, with the development of medical technology, many early and mid-stage cancers can be effectively treated, but unfortunately: cancer patients are generally in the advanced stage when they perceive or detect the disease, and it is difficult to cure. [0003] Diagnosis of diseases through active micro organism...

Claims

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Application Information

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IPC IPC(8): G01N33/50C12M1/36C12M1/34B01L3/00
Inventor 李木
Owner 李木
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