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Folic acid VB12 tablet and preparation method thereof

A technology of folic acid and flakes, which is applied in the field of folic acid VB12 tablets and its preparation, and can solve problems such as the loss of functional components

Active Publication Date: 2016-12-07
北京斯利安健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In view of this, the main purpose of the present invention is to provide a preparation method of folic acid VB12 tablets, which can avoid folic acid and vitamin B 12 The adverse effects caused by thermal degradation on the content or impurities can also solve the problem of content uniformity caused by the large difference between the functional components and their proportions with the excipients, and can also solve the problem of the loss of functional components

Method used

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  • Folic acid VB12 tablet and preparation method thereof
  • Folic acid VB12 tablet and preparation method thereof
  • Folic acid VB12 tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] In this example, the components shown in Table 1 are used as the raw and auxiliary materials to firstly adopt a specific wet granulation process to prepare wet granules, and then adopt the method of fluidized bed drying to prepare folic acid VB12 tablets, wherein the amount of raw and auxiliary materials for 1000 tablets is shown in the table 1.

[0030] Present embodiment folic acid VB12 sheet is prepared according to the following process:

[0031] (1) Weigh folic acid and VB12 according to the prescription amount, and mix them evenly with maltodextrin in an equal amount increasing manner. Specifically, mix VB12 with part of folic acid and then add the remaining folic acid, then mix and add an equal amount of maltose Mix dextrin, then add maltodextrin not more than 3 times of the mixture and mix again, and so on until the maltodextrin is used up, add about 0.4g of water to make the powder slightly moist, use a dry granulator or tablet press Press the mixed powder int...

Embodiment 2

[0072] In this example, the components shown in Table 4 are used as raw materials and supplementary materials to obtain wet granules by using a specific wet granulation process, and then the method of fluidized bed drying is used to prepare folic acid VB12 tablets, wherein the consumption of raw materials and supplementary materials is as shown in the table 4 shows:

[0073] Table 4

[0074]

[0075] Present embodiment folic acid VB12 sheet is prepared according to the following process:

[0076] (1) Weigh folic acid and VB12 according to the prescription amount, and mix them evenly with cyclodextrin in an equal amount increasing manner, specifically, mix VB12 with part of folic acid and then add the remaining folic acid, mix again, and add an equal amount of cyclodextrin Mix dextrin, then add cyclodextrin not more than 3 times of the mixture and mix again, and so on until the cyclodextrin is used up, add about 0.4g of water to make the powder slightly moist, use a dry gra...

Embodiment 3

[0081] In this embodiment, the components shown in Table 5 are used as raw and auxiliary materials to obtain wet granules by a specific wet granulation process, and then the fluidized bed drying method is used to prepare folic acid VB12 tablets, wherein the consumption of raw and auxiliary materials in 1000 tablets is as follows: Table 5 shows:

[0082] table 5

[0083]

[0084] Present embodiment folic acid VB12 sheet is prepared according to the following process:

[0085] (1) Weigh folic acid and VB12 according to the prescription amount, and mix them with crospovidone in equal increments. Specifically, mix VB12 with part of folic acid and then add the remaining folic acid, mix again, and add an equal amount of Mix the crospovidone, then add no more than 3 times the crospovidone and mix, and so on, until the crospovidone is used up, add about 0.4g of water to make the powder slightly damp, use Dry granulator or tabletting machine compresses the mixed powder into flakes...

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Abstract

The invention provides a folic acid VB12 tablet and a preparation method thereof. The preparation method includes: evenly mixing VB12 and folic acid with auxiliary material of a micro porous structure 0.30-2.0m<2> / g in specific surface area, pressing mixed material into a tablet with hardness of the table being controlled to be 2-4kg during pressing, smashing the tablet into fine granules to be evenly mixed with a thinning agent, and using adhesive to perform wet granulation to obtain wet granules, wherein the weight ratio of the folic acid and the VB12 to the auxiliary material of the micro porous structure is 40:0.06-0.20:800-40000; subjecting the wet granules to boiling and drying; regulating the granules, adding in lubricant and tabletting to obtain the folic acid VB12 tablet. By the arrangement, technical problems that a small-dose folic acid VB12 is low in dosage of active components, high in quantity of the auxiliary material, difficult to ensure evenness, poor in constancy of raw materials and difficult in granule drying are solved successfully, and the prepared tablet can meet requirements on effective components, impurities and evenness.

Description

technical field [0001] The invention relates to a nutrient supplement and a preparation method thereof, in particular to a folic acid VB12 tablet and a preparation method thereof. Background technique [0002] Folic acid is an important heat-labile, low-molecular-weight B-group water-soluble vitamin. It was named after it was discovered: vitamin M, vitamin Bc, R factor, etc. It was isolated from spinach in 1941. It is named after its rich content, also known as pteroyl glutamic acid, and its parent compound is composed of three components: pteridine, p-aminobenzoic acid and glutamic acid. Folic acid is a dark yellow substance that is not easily soluble in water and contains one or more glutamyl groups. Most of the naturally occurring folic acid is in the form of polyglutamic acid, which cannot be completely absorbed into the blood. [0003] Folic acid has two ways of active absorption and passive absorption in the body, and the absorption site is mainly in the upper part of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/28A61K31/714A61K31/519A61K47/36A61K47/32A61K47/40A61K47/38A61P3/02
CPCA61K9/2027A61K9/205A61K9/2054A61K9/2059A61K9/28A61K31/519A61K31/714A61K2300/00
Inventor 闫东海常坦然郑少辉王瑾张妮易斌
Owner 北京斯利安健康科技有限公司
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