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Drug containing flavonoid compound composition and application thereof

A technology of compounds and flavonoids, applied in the field of pharmaceuticals, can solve the problems of high dosage and limited efficacy, and achieve the effect of reducing dosage, less toxic and side effects, and improving anticancer function

Inactive Publication Date: 2016-12-07
李贻昆 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned studies all use a kind of flavonoid compound alone, and the current various flavonoid compounds have the defects of limited efficacy and large dosage when used alone

Method used

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  • Drug containing flavonoid compound composition and application thereof
  • Drug containing flavonoid compound composition and application thereof
  • Drug containing flavonoid compound composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0110] Preparation Example 1: Preparation of a flavonoid compound composition containing two active ingredients: one of formononetin (F)+(formononetin (O), actecosin (C) and actecoside (CG) kind)

[0111] Dissolve formononetin, formononetin, verbascoisoflavone and verbascoside in DMSO respectively, and prepare respective DMSO mother solutions (each mother solution has 3 concentrations: 50 μM, 500 μM, 5 mM, used to prepare different final concentration to improve experimental precision). Calculate and measure the required volume of DMSO mother solution according to the final concentration of different active ingredients, combine, and dilute to 300 microliters with the cell culture solution described in Test Example 1. The final concentrations of the active ingredients were: formononetin 20 μM, and formononetin, acteosin and verbascoside respectively 0.5, 1, 5, 10, 20, 40, 70 and 100 μM.

preparation example 2

[0113] Preparation Example 2: Preparation of a flavonoid compound composition containing two active ingredients: F+ (one of O, C and CG)

[0114] Formononetin 40 μM, formononetin, verbascoisoflavone and verbascoside were 0.5, 1, 5, 10, 20, 40, 70, 100 μM respectively.

preparation example 3

[0115] Preparation Example 3: Preparation of a flavonoid compound composition containing three active ingredients: F+ (two of O, C and CG)

[0116] Formononetin 20 μM, formononetin, verbascoisoflavone and verbascoside were 0.5, 1, 5, 10, 20, 40, 70, 100 μM respectively.

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Abstract

The invention relates to application of a flavonoid compound composition in preparation of drugs for treatment and / or prevention of cancer, and also relates to a pharmaceutical composition for treatment and / or prevention of cancer. The flavonoid compound composition can effectively improve the anticancer function, and all active ingredients have a good synergistic effect. The flavonoid compound composition contains at least two flavonoid compounds shown as formula I in the specification as the active ingredients, wherein R1 is hydroxyl or a group shown as the specification, and R2 is H or hydroxyl.

Description

technical field [0001] The present invention belongs to the field of pharmacy, and in particular relates to a medicine containing a flavonoid compound composition and an application of the flavonoid compound composition in preparing medicine for treating and / or preventing cancer. Background technique [0002] In recent years, with the rapid economic growth, the deterioration of the living environment, and the changes in diet and lifestyle, the incidence of cancer has exploded. Currently commonly used chemotherapy drugs are not only expensive, but also cause serious side effects in cancer patients, such as chemotherapy-induced anemia, decreased immune function, and antioxidant function. Therefore, it is of great significance to develop a drug with low price and little side effects for alleviating the pain of cancer patients. [0003] As pure natural plant medicines, traditional Chinese medicine formulas usually have no toxic side effects and can be taken for a long time. Ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P35/00
Inventor 李贻昆詹华强何志民郑玉忠张莉卡希夫·里亚兹阿纳斯塔西娅·马斯洛娃丁显廷余辉
Owner 李贻昆