Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Processing extraction method of radix bupleuri decoction pieces and radix bupleuri composition

An extraction method and composition technology, applied in the field of traditional Chinese medicine extraction, can solve the problems of low active ingredient content, inconvenient taking, and large dosage for patients, and achieve the effects of stable active ingredients, low drying efficiency, and strong applicability

Inactive Publication Date: 2016-12-07
NANJING ZHENGKUAN MEDICAL TECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The Bupleurum bupleuri extraction method in the prior art has a rough and backward process, many impurities, and low content of active ingredients, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Processing extraction method of radix bupleuri decoction pieces and radix bupleuri composition
  • Processing extraction method of radix bupleuri decoction pieces and radix bupleuri composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 1000g of Bupleurum decoction pieces, mix well with vinegar, fry in a pot until the vinegar is completely absorbed and slightly dry, take it out, add 10 times the weight of water, soak for 0.5h, decoct for 1 hour, filter, and add 8 times of medicinal materials to the dregs weight of water, decoct for 1 hour, filter out the medicinal liquid, combine two decoction liquids, concentrate to a relative density of 1.05 at 60°C, add ethanol so that the volume percentage of the alcohol content reaches 75%, stir, stand still, filter, When the filtrate is concentrated to 65°C, the relative density is 1.25, and the ethanol is recovered to obtain a concentrated solution, which is refined with silica gel to obtain an effluent, which is further concentrated, dried, and granulated to obtain Bupleurum granules.

[0022] The processing and extraction method of Bupleurum decoction pieces, the silica gel refining method is as follows: pre-load the selected silica gel into a resin column...

Embodiment 2

[0034] Take 1000g of Bupleurum decoction pieces, mix well with vinegar, fry in a pot until the vinegar is completely absorbed and slightly dry, take it out, add 10 times the weight of water, soak for 0.5h, decoct for 1 hour, filter, and add 8 times of medicinal materials to the dregs weight of water, decoct for 1 hour, filter out the medicinal liquid, combine two decoction liquids, concentrate to a relative density of 1.05 at 60°C, add ethanol so that the volume percentage of the alcohol content reaches 75%, stir, stand still, filter, When the filtrate is concentrated to 65°C, the relative density is 1.25, and the ethanol is recovered to obtain a concentrated solution, which is refined with silica gel to obtain an effluent, which is further concentrated, dried, and granulated to obtain Bupleurum granules.

[0035] The processing and extraction method of Bupleurum decoction pieces, the silica gel refining method is as follows: pre-load the selected silica gel into a resin column...

Embodiment 3

[0040] Take 1000g of Bupleurum decoction pieces, mix well with vinegar, fry in a pot until the vinegar is completely absorbed and slightly dry, take it out, add 10 times the weight of water, soak for 0.5h, decoct for 1 hour, filter, and add 8 times of medicinal materials to the dregs weight of water, decoct for 1 hour, filter out the medicinal liquid, combine two decoction liquids, concentrate to a relative density of 1.05 at 60°C, add ethanol so that the volume percentage of the alcohol content reaches 75%, stir, stand still, filter, When the filtrate is concentrated to 65°C, the relative density is 1.25, and the ethanol is recovered to obtain a concentrated solution, which is refined with silica gel to obtain an effluent, which is further concentrated, dried, and granulated to obtain Bupleurum granules.

[0041] The processing and extraction method of Bupleurum decoction pieces, the silica gel refining method is as follows: pre-load the selected silica gel into a resin column...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Specific surfaceaaaaaaaaaa
Pore volumeaaaaaaaaaa
Specific surfaceaaaaaaaaaa
Login to View More

Abstract

The invention provides a processing extraction method of radix bupleuri decoction pieces. The method comprises the steps that radix bupleuri is uniformly mixed with vinegar, put into a pot to be stir-fried till the vinegar is completely absorbed and radix bupleuri is slightly dry and then taken out, water of which the weight is 10 times the weight of radix bupleuri is added, soaking is conducted for 0.5 h, decocting is conducted for one hour, and filtering is conducted; water of which the weight is 8 times the weight of the medicinal material is added into medicine residues, decocting is conducted for one hour, and medicine liquid is filtered; decoction solutions obtained in two times are mixed and concentrated till the relative density is 1.05 at 60 DEG C, ethyl alcohol is added to enable the alcohol volume percent to reach 75%, stirring, standing and filtering are sequentially conducted, filtrate is concentrated till the relative density is 1.25 at 65 DEG C, ethyl alcohol is recycled, and concentrated liquor is obtained; refining is conducted through silica gel, the pre-selected silica gel is contained in a resin column, the concentrated liquor is diluted with purified water and passes through a reverse-phase silica gel column, impurities in liquid are removed, all effluent is collected, concentrating continues to be conducted, concentrated liquor is dried and granulated, and then radix bupleuri granules are obtained. The radix bupleuri granules prepared through the method are high in saikoside content, and a radix bupleuri composition is prepared from the radix bupleuri granules, ligustilide and quercetin through compatibility.

Description

technical field [0001] The invention relates to the technical field of extracting traditional Chinese medicines, in particular to a method for processing and extracting Bupleurum decoction pieces and a Bupleurum composition. Background technique [0002] The Bupleurum bupleuri extraction method in the prior art has rough and backward process, many impurities, and low active ingredient content, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product. Contents of the invention [0003] Purpose of the invention: In order to solve the above problems, the purpose of the present invention is to provide a method for processing and extracting Bupleurum decoction pieces and a Bupleurum composition. [0004] Technical scheme: the purpose of the present invention is achieved by the following scheme: [0005] A method for processing and extracting Bupleurum decoction pieces, the preparation method is: ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/233A61K9/16A61P31/04B01D1/00B01D1/30B01F13/10F26B21/00F26B23/06F26B21/10F26B25/00A61K31/365A61K31/352
CPCB01D1/00B01D1/0017B01D1/30F26B21/00F26B21/10F26B23/06F26B25/00A61K9/16A61K31/352A61K31/365A61K36/233A61K2236/55A61K2236/39A61K2236/331B01F33/406B01F33/402A61K2300/00
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com