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A kind of chicken coccidiosis vaccine and its application

A chicken coccidiosis and vaccine technology, which is applied in the field of chicken coccidiosis vaccines, can solve the problems of shortening the time for vaccine immunity to establish protection, achieve good economic benefits, increase breeding benefits, and slow down the decline in production performance

Active Publication Date: 2020-01-17
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems existing in the existing coccidiosis vaccine immunization, the object of the present invention is to provide a new chicken coccidiosis vaccine immunization method, change the existing coccidiosis vaccine immunization strategy or immunization program, and shorten the establishment of vaccine immunization The duration of protection, thereby reducing the negative effects of chickens ingesting the oocysts excreted after self-vaccination, and at the same time providing good immune protection against coccidiosis infection for chickens

Method used

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  • A kind of chicken coccidiosis vaccine and its application
  • A kind of chicken coccidiosis vaccine and its application
  • A kind of chicken coccidiosis vaccine and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0043] This example is used to illustrate the immunization method described in the present invention.

[0044] Such as figure 1 As shown, 1-day-old chicks were orally immunized with coccidiosis vaccine (dose 550±10% oocyst / feather), normally fed feed without anticoccidial drugs, free to drink water, 2 days after the initial immunization (3-day-old chicks ), carry out re-immunization with the same dose (550±10% oocyst / feather).

Embodiment 2

[0046] The difference between this example and Example 1 is that the re-immunization time is 1 day after the initial immunization (the chicks are 2 days old).

Embodiment 3

[0048] The difference between this example and Example 1 is that the re-immunization time is 3 days after the initial immunization (the chick is 4 days old).

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Abstract

The invention relates to the field of biological immunity, and particularly discloses a fowl globidiosis vaccine and application thereof. The transgenic technology is used for constructing transgenosis coccidium expressing related factors (including a cell factor, ligand of immunoreceptor, somatic antigen capable of adjusting immunity response between different coccidium species) for adjusting immunity response intensity of a host; compared with wild type coccidium, the transgenosis coccidium has higher immunogenicity, is safer and more effective serving as a component of the novel globidiosis vaccine and can fast construct immunity protection force. With the transgenosis coccidium serving as the vaccine component, the immunity effect of an existing globidiosis vaccine can be further promoted, the side effects caused by immunity of the globidiosis vaccine are reduced, and the globidiosis vaccine has good economic benefits and broad application prospects.

Description

technical field [0001] The invention relates to the field of biological immunity, in particular to a chicken coccidiosis vaccine. Background technique [0002] Chicken coccidiosis seriously endangers the health of chicken flocks and restricts the output of meat and egg products. It is one of the important diseases that limit the development of intensive chicken farming. The pathogens were 7 species of Eimeria coccidia, which parasitized in different parts of the intestinal tract. Prevention and control strategies rely on drug prevention and vaccination. The coccidiosis vaccine with live oocysts as the vaccine component has a good effect on the prevention and control of coccidiosis. It is the only protozoan live vaccine approved for marketing so far, and it is widely used in the prevention of breeders and laying hens. The prevention of coccidiosis in broiler chickens is controlled by drugs or the coccidiosis vaccination with weakened live oocysts as vaccine components. How...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/012A61P33/02
CPCA61K39/012A61K2039/542A61K2039/545A61K2039/552A61K2039/57
Inventor 索勋汤新明刘贤勇索静霞
Owner CHINA AGRI UNIV
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