Plush thread bioreactor artificial liver system

Abstract

The invention discloses a plush thread type bioreactor artificial liver system, which includes a plasma separation / reinfusion circulation part and a bioreactor circulation part, and the two parts are connected to each other through pipelines; the plasma separation / reinfusion circulation part includes sequentially connected blood Input port, blood pump, arterial jug, plasma separator, venous jug and blood return port; plasma separator is equipped with blood inlet, plasma outlet and blood cell outlet; blood inlet is connected with the outlet of arterial jug; bioartificial liver reaction The reactor comprises a reactor shell and a plurality of plush wires and a plurality of hollow fiber tubes arranged in the inner cavity of the reactor shell; the plurality of plush threads and the plurality of hollow fiber tubes are arranged in parallel and alternately arranged at intervals. The beneficial effects of the present invention are: significantly increasing the area of ​​the hepatocytes that can adhere to the wall in the reactor, improving the uniformity of the distribution of the hepatocytes, maintaining good cell activity, and being conducive to the maximum play of the function of the hepatocytes, thereby achieving the best good therapeutic effect.

Description

technical field [0001] The invention relates to the technical field of bioartificial liver, in particular to an artificial liver system of plush thread type bioreactor. Background technique [0002] my country is the country with the most serious liver disease in the world, with more than 900,000 new cases of liver failure each year, and about 500,000 liver failure patients die each year due to lack of effective treatment. There is only one chance of cure, that is, liver transplantation, but due to the difficulty in obtaining livers, the long waiting time, or no chance to get a donor liver at all, most patients have no chance of survival at all. Therefore, an artificial liver system is urgently needed to maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the patient's own liver recovery. [0003] The traditional artificial liver (that is, physical artificial liver) has greatly hindered its clinical application due to its...

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Problems solved by technology

[0006] The purpose of the present invention is to overcome the defects of uneven distribution of hepatocytes in the reactor in the existing bioartificial liver system, low adhesion rate, and poor cell activity, and provide a method that can effectively increase the area of ​​hepatocyte adhesion and promote the hepatocytes in the bioartificial liver system. Adhesive growth in the bioartificial liver reactor can increase the growth density and activity of liver cells, online monitoring of biochemical indicators, constant temperature heating of the bioartificial liver reactor and non-interrupted treatment of patients. artificial liver system

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