Plush-type bioreactor artificial liver system

Abstract

The invention discloses a plush-type bioreactor artificial liver system. The plush-type bioreactor artificial liver system comprises a plasma separating / recirculating part and a bioreactor circulating part which are mutually connected through a pipe, wherein the plasma separating / recirculating part comprises a blood transfusion port, a blood pump, an arterial ampulla, a plasma separator, a venous ampulla and a blood retransfusion port which are sequentially connected; a blood inlet, a plasma outlet and a blood cell outlet are formed in the plasma separator; the blood inlet is communicated with the outlet of the arterial ampulla; an artificial liver bioreactor comprises a reactor housing, and a plurality of pieces of plush and a plurality of hollow fiber tubes, which are arranged inside the inner chamber of the reactor housing; the plurality of pieces of plush and the plurality of hollow fiber tubes are arranged in parallel and are alternately spaced. The plush-type bioreactor artificial liver system has the beneficial effects as follows: the plush-type bioreactor artificial liver system significantly increases the adherent area of liver cells in the reactor, improves the uniformity of liver cell distribution, can maintain good cell activity, and benefits maximum achievement of functions of the liver cells, so that the best therapeutic effect is achieved.

Description

technical field [0001] The invention relates to the technical field of bioartificial liver, in particular to an artificial liver system of plush thread type bioreactor. Background technique [0002] my country is the country with the most serious liver disease in the world, with more than 900,000 new cases of liver failure each year, and about 500,000 liver failure patients die each year due to lack of effective treatment. There is only one chance of cure, that is, liver transplantation, but due to the difficulty in obtaining livers, the long waiting time, or no chance to get a donor liver at all, most patients have no chance of survival at all. Therefore, an artificial liver system is urgently needed to maintain the patient's life, waiting for the opportunity of liver transplantation, or the opportunity of the patient's own liver recovery. [0003] The traditional artificial liver (that is, physical artificial liver) has greatly hindered its clinical application due to its...

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Problems solved by technology

[0006] The purpose of the present invention is to overcome the defects of uneven distribution of hepatocytes in the reactor in the existing bioartificial liver system, low adhesion rate, and poor cell activity, and provide a method that can effectively increase the area of ​​hepatocyte adhesion and promote the hepatocytes in the bioartificial liver system. Adhesive growth in the bioartificial liver reactor can increase the growth density and activity of liver cells, online monitoring of biochemical indicators, constant temperature heating of the bioartificial liver reactor and non-interrupted treatment of patients. artificial liver system

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