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Chinese medicinal composition for reversing tumor multidrug resistance (MDR) and preparation method thereof

A technology of multi-drug resistance and composition, which is applied in the direction of drug combination, antineoplastic drugs, and pharmaceutical formulations, and can solve the problem of not many traditional Chinese medicine compound compositions.

Inactive Publication Date: 2017-01-11
GUANGZHOU JIAYUAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the invention patent reports on the preparation of tumor multidrug resistance reversal agents basically focus on chemical drugs and traditional Chinese medicine monomer components, and there are not many traditional Chinese medicine compound compositions that combine traditional Chinese medicine theory and clinical efficacy

Method used

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  • Chinese medicinal composition for reversing tumor multidrug resistance (MDR) and preparation method thereof
  • Chinese medicinal composition for reversing tumor multidrug resistance (MDR) and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 Chinese medicine composition of the present invention (taking ten times raw material proportioning amount as example)

[0017] 1. Weigh each API according to the following weight ratio

[0018] 100 grams of edelweiss, 100 grams of huaxiangshu, 50 grams of red head grass, 50 grams of red back leaves and 50 grams of saxifrage for later use.

[0019] 2. Mix the medicinal materials according to the above weight ratio, add 3 times the amount of water to soak for 1 hour, heat and decoct for 1.5 hours, filter, add 2 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 0.5 hours, pour out the supernatant; when the supernatant is concentrated to a relative density of 1.08, enter the spray dryer, the inlet air temperature is controlled at 120°C, the outlet air temperature is 105°C, the atomizer speed is 20 rpm, and the feed rate is 3ml / minute, 18 grams of spray-dried...

Embodiment 2

[0020] The preparation of embodiment 2 Chinese medicine composition of the present invention (taking ten times raw material proportioning amount as example)

[0021] 1. Weigh each API according to the following weight ratio

[0022] 300 grams of edelweiss, 300 grams of huaxiangshu, 250 grams of red head grass, 250 grams of red back leaves and 200 grams of saxifrage for later use.

[0023] 2. Mix the medicinal materials according to the above weight ratio, add 3 times the amount of water to soak for 1 hour, heat and decoct for 1.5 hours, filter, add 2 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 0.5 pour out the supernatant; when the supernatant is concentrated to a relative density of 1.10, it enters the spray dryer, the inlet air temperature is controlled at 130°C, the outlet air temperature is 120°C, the atomizer speed is 30 rpm, and the feed rate is 5ml per minute to obtain 70 grams of ...

Embodiment 3

[0024] Embodiment 3 The preparation of Chinese medicine composition of the present invention (taking ten times raw material proportioning amount as example)

[0025] 1. Weigh each API according to the following weight ratio

[0026] 120 grams of edelweiss, 120 grams of huaxiangshu, 100 grams of red head grass, 100 grams of red back leaves and 100 grams of saxifrage for later use.

[0027] 2. Mix the medicinal materials according to the above weight ratio, add 3 times the amount of water to soak for 1 hour, heat and decoct for 1.5 hours, filter, add 2 times the amount of water to the medicinal residue, heat and decoct for 1 hour, filter, combine the two filtrates, and let stand for 0.5 hours, pour out the supernatant; when the supernatant is concentrated to a relative density of 1.09, enter the spray dryer, the inlet air temperature is controlled at 125°C, the outlet air temperature is 110°C, the atomizer speed is 25 rpm, and the feed rate is 4ml per minute to obtain 30 grams ...

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Abstract

The invention discloses a Chinese medicinal composition for reversing tumor MDR and a preparation method of the Chinese medicinal composition for reversing tumor MDR, and belongs to the field of traditional Chinese medicines; the Chinese medicinal herbs of leontopodium leontopodioides, platycarya strobilacea, blumea lacera, alchornea trewioides and saxifraga stolonifera are taken as the raw materials and combined and prepared into active components.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for reversing tumor multidrug resistance, which belongs to the field of traditional Chinese medicines. [0002] technical background [0003] Malignant tumors seriously affect human health. Chemotherapy is currently one of the three major means of treating malignant tumors. In clinical applications, there are often practical problems such as insensitivity to chemotherapy or the failure of chemotherapy to achieve the expected effect, or patients are still sensitive at the beginning of chemotherapy, and chemotherapy Drug resistance occurs during the course of the operation, and drug resistance leads to tumor metastasis, recurrence, etc., which often occur after surgery and chemotherapy, and eventually leads to death. Multidrug resistance (MDR) of tumor cells to anti-tumor drugs is a common factor leading to the failure of tumor chemotherapeutic drugs. A variety of anti-tumor drugs that h...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61P35/00
CPCA61K36/52A61K36/185A61K36/28A61K36/47A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 王素侠王琦
Owner GUANGZHOU JIAYUAN PHARMA TECH
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