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Radix asparagi and radix ophiopogonis drop pill preparation method

A technology of dripping pills and asparagus, which is applied in the field of preparation of Erdong dripping pills, can solve the problems of no report on the preparation method of Erdong dripping pills, no reference to the preparation method of dripping pills, and large dosage of Erdong cream, and achieve Easy to carry and take, high degree of automation, quick effect

Inactive Publication Date: 2017-01-11
CHENGDE MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The disadvantages of Erdong ointment are large dosage, poor stability relative to solid preparations, easy to mold and corruption, reduced drug efficacy, and inconvenient to carry, etc.
[0010] CN 101239150 A discloses an oral preparation of Erdong and its preparation method, which involves the preparation method of 8 traditional Chinese medicines such as Radix Asparagus. The prescription is not consistent with the present invention, nor does it involve the preparation method of dripping pills; Saponin D dripping pills and its preparation method are different from the medicines used in the present invention; literature search has not found any reports about Erdong dropping pills and its preparation method

Method used

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  • Radix asparagi and radix ophiopogonis drop pill preparation method

Examples

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Effect test

Embodiment 1

[0105] Embodiment 1: the preparation of Erdong dripping pills

[0106] The implementation steps of this embodiment are as follows:

[0107] A, preparation of Asparagus and Ophiopogon japonicus extract

[0108] According to the ratio of raw material in grams to water in ml of 1:6, add asparagus or Ophiopogon japonicus raw materials into water and soak for 1.0h, then extract at a slight boil for 55min, filter, and continue to repeat the operation twice in this way for the filter residue , the collected filtrates were combined;

[0109]Then allow the combined filtrate to be concentrated to one-tenth of its original volume on a rotary evaporator sold under the trade name N-1100 by EYELA Company, and then add 95% ethanol solution by volume to make the ethanol concentration of the combined filtrate It reached 80% by volume, left for 12 hours, centrifuged at 5000r / min for 21 minutes, and the obtained precipitate was dissolved in water at a temperature of 45°C, then placed at a temp...

Embodiment 2

[0115] Embodiment 2: the preparation of Erdong dripping pills

[0116] The implementation steps of this embodiment are as follows:

[0117] A, preparation of Asparagus and Ophiopogon japonicus extract

[0118] According to the ratio of raw materials in grams to water in ml of 1:5, add asparagus or Radix Ophiopogon japonicus raw materials into water and soak for 0.5h, then extract at a slight boil for 65min, filter, and continue to repeat the operation 3 times in this way for the filter residue , the collected filtrates were combined;

[0119] Then allow the combined filtrate to be concentrated to one-tenth of its original volume on a rotary evaporator sold under the trade name N-1100 by EYELA Company, and then add 95% ethanol solution by volume to make the ethanol concentration of the combined filtrate It reached 80% by volume, left for 24 hours, centrifuged at 6000r / min for 15 minutes, and the obtained precipitate was dissolved in water at a temperature of 50°C, then placed...

Embodiment 3

[0125] Embodiment 3: Preparation of Erdong Dropping Pills

[0126] The implementation steps of this embodiment are as follows:

[0127] A, preparation of Asparagus and Ophiopogon japonicus extract

[0128] According to the ratio of raw material in grams to water in ml of 1:10, add asparagus or Ophiopogon japonicus raw materials into water and soak for 0.7h, then extract at a slight boil for 60min, filter, and continue to repeat the operation 4 times in this way for the filter residue , the collected filtrates were combined;

[0129] Then allow the combined filtrate to be concentrated to one-tenth of its original volume on a rotary evaporator sold under the trade name N-1100 by EYELA Company, and then add 95% ethanol solution by volume to make the ethanol concentration of the combined filtrate 80% by volume, placed for 16 hours, centrifuged at 3000r / min for 25 minutes, the obtained precipitate was dissolved in water at a temperature of 55°C, then placed at a temperature of -5...

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Abstract

The invention relates to a radix asparagi and radix ophiopogonis drop pill preparation method. The method includes the steps of preparing radix asparagi extracts and radix ophiopogonis extracts, mixing radix asparagi and radix ophiopogonis, conducting dropping and the like. A radix asparagi and radix ophiopogonis drop pill can remarkably reduce the cough frequency of rats in a cough inducing and asthma inducing instrument, the cough frequency reduced by the radix asparagi and radix ophiopogonis drop pill is higher than that reduced by radix asparagi and radix ophiopogonis paste, and the drop pill has a better effect on treating lung heat yin deficiency type coughing rats.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of traditional Chinese medicine pharmacy. The invention relates to a preparation method of Erdong dripping pills. [0003] 【Background technique】 [0004] Erdong Gao is recorded in the 2015 edition of "Chinese Pharmacopoeia", and the prescription is 500 grams of Asparagus and 500 grams of Radix Ophiopogon japonicus. The preparation method is to decoct the two traditional Chinese medicines with water for 3 times, the first decoction time is 3 hours, the second and third times are 2 hours respectively, the decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.21-1.25 (80°C) clear paste. Add 50g of refined honey to every 100g of clear paste, and mix to obtain the Erdong paste. It has the effect of nourishing yin and nourishing the lungs. It is used for dry cough with less phlegm, bloody sputum, dry nose and sore throat caused by deficiency of lung yin. The do...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/20A61P11/14F26B5/06
CPCA61K9/2031A61K36/8965A61K36/8968A61K2236/331A61K2236/39A61K2236/51A61K2236/53F26B5/06A61K2300/00
Inventor 刘喜纲李喜凤王钊贾瑶瑶周艳玲张梓傲
Owner CHENGDE MEDICAL UNIV
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