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Dietary compositions for reducing blood glucose levels and for weight management

一种血糖水平、组合物的技术，应用在食物科学、药物组合、药物输送等方向，能够解决未满足等问题

Inactive Publication Date: 2017-02-22
MARMAR INVESTMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] There remains an unmet need for compositions of dietary supplements that exhibit significant therapeutic effects in diseases and disorders associated with abnormal blood glucose levels

Method used

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  • Dietary compositions for reducing blood glucose levels and for weight management
  • Dietary compositions for reducing blood glucose levels and for weight management
  • Dietary compositions for reducing blood glucose levels and for weight management

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Example 1: Effect of a single plant extract on postprandial blood glucose levels in vivo

[0148] The experiment was carried out on 96 male Wistar rats with an average body weight of 381.2±16.6 g, housed at the IARFR PAS in Olsztyn. Each study group consisted of 12 rats. Animals were maintained in individual cages in a ventilated room at a constant temperature of about 22°C, a controlled relative humidity of about 60%, and appropriate light (day / night, 12 / 12 hours). During the experimental period, the animals were fed with standard laboratory rodent mix. Before the first measurement of blood glucose levels, rats were deprived of food for 12 hours while maintaining constant water uptake. On the day of the experiment, rats were weighed and fasting blood glucose measurements were taken via a scalpel incision at the tail. Animals then received predetermined amounts of aqueous solutions of plant extracts, acarbose as a positive control (PC) or water as a negative control ...

Embodiment 2

[0163] Example 2: Combination of plant extracts reduces blood sugar levels in vivo

[0164] The effect of the combination of plant extracts was tested in an experiment with 50 male Wistar rats with an average body weight of 294.9±21.0 g, housed at IARFR PAS in Olsztyn. Each study group consisted of 10 rats. Rats were maintained in individual cages with ventilation at a constant temperature of about 22°C, a controlled relative humidity of about 60%, and appropriate light (day / night, 12 / 12 hours). During the experimental period, rats were fed with a standard laboratory rodent mixture. Before the first measurement of blood glucose levels, rats were deprived of food for 12 hours while maintaining constant water uptake. On the day of the experiment, rats were weighed and fasting blood glucose measurements were taken via a scalpel incision at the tail. The rats were then administered water (negative control), acarbose (positive control) or an aqueous solution of a predetermined c...

Embodiment 3

[0177] Example 3: Combination of Plant Extracts Reduces Blood Glucose Levels in Obese Rats

[0178]To evaluate whether administration of plant extracts as dietary supplements can positively affect blood glucose levels in animals fed a high-fat diet, in vivo experiments were carried out in two phases: an initial phase and a test phase, each lasting 10 weeks. During the initial phase, groups of 40 Wistar rats approximately 35 days old from a single pack of IARFR animal houses were fed a commercial high-fat diet C 1090-45 consisting of (Altromin GmbH, Lage, Germany): 21% crude protein, 22% crude fat, 3.95% crude fiber and 5.1% crude ash. A second group of 10 rats from the same pack and of the same age was fed a commercial low-fat diet C 1090-10 (Altromin GmbH, Lage, Germany) consisting of: 21% crude protein, 3.9 % crude fat, 4.0% crude fiber and 4.7% crude ash. The above diets differ significantly in the metabolizable energy (ME) obtained from the individual components. Detail...

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Abstract

The present invention provides dietary compositions comprising mulberry extract, coffee extract, bean extract, optionally, dietary fibers, and a nutraceutically acceptable carrier. The present invention further provides methods for preventing the increase in postprandial hyperglycemia and hypoglycemia, hyperinsulinemia and diseases and disorders associated therewith, including, endothelial dysfunction, inflammatory conditions, oxidative stress, hyperlipidemia, and consecutive pathologies like insulin resistance, diabetes, visceral obesity, hypertension and cardiovascular diseases.

Description

[0001] field of invention [0002] The present invention provides a dietary composition comprising mulberry extract, coffee extract, bean extract, optionally dietary fiber and a nutraceutically acceptable carrier. The invention also provides methods for preventing postprandial hyperglycemia and hypoglycemia, increased hyperinsulinemia and diseases and disorders associated therewith including endothelial dysfunction, inflammatory conditions, oxidative stress, hyperlipidemia Diseases and continuum of pathologies such as insulin resistance, diabetes, visceral obesity, hypertension and cardiovascular disease. [0003] Background of the invention [0004] The high incidence of metabolic disorders in humans and their associated effects on health and mortality pose a major threat to public health. These metabolic disorders include obesity and type II diabetes, among others. However, since the claimed satisfactory curative effect is accompanied by many side effects and the long-term ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/08A61K47/46A61P3/10A61P3/00A23L2/52A23L7/109A23L33/105A23L33/21A23L23/00A61K31/7004A61K31/733A61K31/736A23L33/00
CPCA23L2/52A61K9/0053A61K9/08A61K31/7004A61K31/733A61K31/736A61K36/48A61K36/605A61K36/74A61K47/46A61K2300/00A23L7/109A23L33/30A23L33/105A23L33/21A23L23/00A61P3/00A61P3/04A61P3/06A61P3/08A61P3/10A23V2002/00
Inventor 马雷克·奥尔洛夫斯基马尔辛·克罗特奇夫斯基卡塔日娜·比林-马尔恰克
Owner MARMAR INVESTMENT
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