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Silicone acrylamide copolymer

A technology of acrylamide monomers and copolymers, used in instruments, optical components, optics, etc., can solve the problems of reduced transparency, difficulty, loss of transparency of copolymers, etc.

Inactive Publication Date: 2017-02-22
JOHNSON & JOHNSON VISION CARE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the amount of crosslinker is reduced, the modulus decreases, but until the modulus decreases sufficiently, the copolymer loses transparency, making it difficult to achieve both low modulus and transparency
Furthermore, when trying to reduce the modulus by using a variety of bisacrylamides with extended methylene chains, there was no significant difference in modulus compared to MBA, and when the amount of crosslinker was reduced, the transparency decreased, making it difficult to achieve both low modulus and transparency

Method used

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  • Silicone acrylamide copolymer
  • Silicone acrylamide copolymer
  • Silicone acrylamide copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] The following were mixed and stirred: bisacrylamide SiBA (0.016 g, 2.0 parts by mass) obtained in Synthesis Example 1, a monofunctional linear silicone acrylamide monomer represented by the following formula (X1)

[0198]

[0199] (0.462g, 56.06 parts by weight), DMA (0.208g, 25.27 parts by weight), a non-silicone acrylamide monomer represented by the following formula (H1)

[0200]

[0201] (0.058g, 7 parts by weight), polyvinylpyrrolidone (PVP K90, 0.066g, 8 parts by weight), ultraviolet absorber 2-(2'-hydroxy-5'-methacryloyloxyethyl)-2H - Benzotriazole (0.018 g, 2.22 parts by mass), tert-amyl alcohol (TAA, 0.681 g) and photoinitiator Irgacure 819 (0.002 g, 0.25 parts by mass). The resulting monomer mixture was degassed under an argon atmosphere. In a glove box in a nitrogen atmosphere, the monomer mixture was filled into the lens-shaped slit of a mold made of transparent resin (front curve side: ZEONOR, basic curve side: polypropylene), and irradiated with lig...

Embodiment 2 and 3

[0206] A lens-shaped sample was obtained by performing polymerization in the same manner as in Example 1 except that the composition was changed as shown in Table 1. Table 1 shows the appearance, transmittance, water content, modulus, elasticity and zero stress time of the obtained lens shape samples.

Embodiment 4

[0208] Polymerization was carried out in the same manner as in Example 1 to obtain a lens-shaped sample, except that: Synthesis Example 2 used the obtained SiBA 1000 as a bisacrylamide monomer, and Synthesis Example 1 used the obtained SiBA as bisacrylamide monomer, and the composition was changed as shown in Table 1. Table 1 shows the appearance, transmittance, water content, modulus, elasticity and zero stress time of the obtained lens shape samples.

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Abstract

The present invention relates to a silicone acrylamide copolymer of high acrylamide monomer content which has transparency and low modulus, employing the following configuration. The copolymer is suitably used for various kinds of medical devices, particularly ophthalmic lenses such as a contact lens, an intraocular lens, an artificial cornea, and is especially suitable for a contact lens. A copolymer comprising (A) a multi-functional (meth)acrylamide monomer having at least one siloxane bond and at least two (meth)acrylamide groups within a molecule and (B) a mono-functional linear silicone (meth)acrylamide monomer.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 61 / 972,847, filed March 31, 2014, and U.S. Patent Application Serial No. 14 / 670,981, filed March 27, 2015; both titled "SILICONE ACRYLAMIDECOPOLYMER", the contents of which are incorporated by reference. technical field [0003] The present invention relates to silicone acrylamide copolymers which are particularly suitable for use in medical devices such as ophthalmic lenses, endoscopes, catheters, infusion tubes, air tubes, stents, sheaths, cuffs, tube connectors, infusion Ports, drainage bags, blood circuits, wound covering materials and many types of drug carriers, especially contact lenses, intraocular lenses and artificial corneas. Background technique [0004] In recent years, silicone hydrogels have become well known as materials for continuous wear contact lenses. A silicone hydrogel obtained by combining a silicone component with a hydrophilic com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F230/08C08F290/06C08F220/58
CPCC08F230/08C08F290/068C08F220/54C08F226/10C08F220/58C08F222/38C08F222/385C08F30/08C08L39/06C08L43/04G02B1/043C08L2203/02C08F220/56G02C7/04
Inventor 田宫竜太藤泽和彦中村正孝T.L.马吉奥M.C.图纳格M.R.克拉克
Owner JOHNSON & JOHNSON VISION CARE INC