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Extraction method of salvianolic acid B

An extraction method and technology of salvianolic acid, applied in the field of traditional Chinese medicine extraction, can solve the problems of reduced content and yield of salvianolic acid B, complex process of danshensu, complicated process, etc., to achieve reduced content and yield, and not easy to decompose and destroy , The effect of simple process

Inactive Publication Date: 2017-03-08
GUIZHOU JINGFENG INJECTION
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  • Abstract
  • Description
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Problems solved by technology

[0007] Aiming at the difficult 100% separation of salvianolic acid B in the salvianolic acid B extraction process in the prior art, and the long decoction time in the process of extracting salvianolic acid B with purified water as the extraction solvent, more impurities are dissolved , the extracted salvianolic acid B is easily oxidized and decomposed into danshensu with long-term decoction, resulting in a significant reduction in the content and yield of salvianolic acid B, complex technological process, and high production costs; and the existing supercritical carbon dioxide extraction Danshensu process is relatively complicated and other problems, the invention provides a kind of extraction method of salvianolic acid B

Method used

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  • Extraction method of salvianolic acid B
  • Extraction method of salvianolic acid B
  • Extraction method of salvianolic acid B

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Embodiment 1

[0045] The present embodiment provides a kind of extraction method of salvianolic acid B, described method is:

[0046] (1) Grind the salvia miltiorrhiza medicinal material until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure acid water with a pH of 3.06 as the entrainer, the amount of the entrainer is 1:6 (W / V), and CO 2 As an extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 30MPa, and the temperature is 50°C; the separation pressure of the first separation tank is 10MPa, and the temperature is 40°C; the separation pressure of the second separation tank is 6MPa, and the temperature is 40°C ; The flow rate of the extractant is 16L / h; the extraction time is 90min; 1 time of supercritical extraction is carried out to obtain the extract;

[0047] (2) Concentrate the extract obtained in step (1) by rotary evaporation at 50° C. to obtain salvianolic acid B.

[0048] De...

Embodiment 2

[0055] The present embodiment provides a kind of extraction method of salvianolic acid B, described method is:

[0056] (1) Grind the salvia miltiorrhiza medicinal material until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure acid water with a pH of 3.30 as the entrainer, the amount of the entrainer is 1:5 (W / V), and CO 2 As an extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 32MPa, and the temperature is 55°C; the separation pressure of the first separation tank is 15MPa, and the temperature is 45°C; the separation pressure of the second separation tank is 8MPa, and the temperature is 42°C ; The flow rate of the extractant is 14L / h; the extraction time is 90min; 1 time of supercritical extraction is carried out to obtain the extract;

[0057] (2) Concentrate the extract obtained in step (1) by rotary evaporation at 50° C. to obtain salvianolic acid B.

[0058] De...

Embodiment 3

[0065] The present embodiment provides a kind of extraction method of salvianolic acid B, described method is:

[0066] (1) Grind the salvia miltiorrhiza medicinal material until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure acid water with a pH of 3.50 as the entrainer, the amount of the entrainer is 1:10 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 33MPa, and the temperature is 60°C; the separation pressure of the first separation tank is 20MPa, and the temperature is 50°C; the separation pressure of the second separation tank is 10MPa, and the temperature is 45°C ; The flow rate of the extractant is 12L / h; the extraction time is 90min; 1 time of supercritical extraction is carried out to obtain the extract;

[0067] (2) Concentrate the extract obtained in step (1) by rotary evaporation at 50° C. to obtain salvianolic acid B.

[0068]...

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Abstract

The invention provides an extraction method of salvianolic acid B. The method comprises the following steps of (1) salvia miltiorrhiza medicinal materials subjected to pretreatment are fed into a super-critical CO2 extraction device; acid water with the pH being 2 to 4 is used as an entrainer to perform super-critical extraction to obtain an extraction solution; (2) the extraction solution obtained in the step (1) is subjected to rotary evaporateion concentration until no water exists to obtain salvianolic acid B. The acid water with the pH being 2 to 4 is used as the entrainer, the salvianolic acid B in the salvia miltiorrhiza medicinal materials is directly extracted out in one step through super-critical CO2 extraction device. The method provided by the invention has the advantages that the extraction efficiency is high; no solvent residue toxicity exists; the extraction separation steps are greatly reduced; the natural active ingredients and heat-sensitive ingredients (salvianolic acid B) cannot be easily decomposed or damaged, the natural features of the extracts can be maintained to the maximum degree, and the selective separation can be realized; the extraction method can be widely applied to natural substance extraction; the problem in the prior art can be effectively avoided.

Description

technical field [0001] The invention belongs to the technical field of extracting traditional Chinese medicines, and relates to a method for extracting salvianolic acid B, in particular to a method for extracting salvianolic acid B, a target component of salvia miltiorrhiza. Background technique [0002] Salvianolic acid B, also known as salvianolic acid B or salvianolic acid B, is a brownish-yellow dry powder. The pure product is off-white powder. Its structure is as follows: [0003] [0004] Salvianolic acid B exists in the form of different salts (such as K+, Ca2+, Na+ or NH4+ and other complex forms), which is more unstable than Danshensu, and it is easy to hydrolyze to form Danshensu in the process of high temperature. [0005] For a long time, in the field of extraction, purification and refinement of salvianolic acid B in industrial production, most of the traditional Chinese medicine decoction pieces are directly extracted with purified water, and by optimizing d...

Claims

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Application Information

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IPC IPC(8): C07D307/86
CPCC07D307/86Y02P20/54
Inventor 冯世明马贤鹏毕昌琼罗斌郁华军沈万燕
Owner GUIZHOU JINGFENG INJECTION
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