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Allogenic decalcified bone material used for re-shaping and filling of nose, and preparation method thereof

An allogeneic, demineralized bone technology, used in prostheses, nose implants, medical science, etc., can solve the problems of complex production process, prone to displacement and wear, and achieve the effect of preventing pain and preventing movement

Inactive Publication Date: 2017-03-15
大连裕辰科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a material for filling allogeneic decalcified bone in rhinoplasty and a preparation method thereof, so as to solve the problems in the prior art that the production process is relatively complicated and prone to displacement and wear.

Method used

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  • Allogenic decalcified bone material used for re-shaping and filling of nose, and preparation method thereof
  • Allogenic decalcified bone material used for re-shaping and filling of nose, and preparation method thereof
  • Allogenic decalcified bone material used for re-shaping and filling of nose, and preparation method thereof

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preparation example Construction

[0041] refer to image 3 As shown, the present invention also proposes a preparation method for filling allogeneic decalcified bone materials for rhinoplasty, comprising the following steps:

[0042] A) Bone extraction, allogeneic cartilage is obtained in a sterile environment, wherein the allogeneic cartilage is non-autologous rib bone, non-autologous ear cartilage.

[0043] B) treatment, the obtained allogeneic cartilage is degreased, decalcified, deproteinized and sterilized sequentially;

[0044] C) Sculpting, sculpting the allogeneic cartilage after the above treatment into the required shape.

[0045] Concrete process in the step B of the present invention comprises:

[0046] (1) immersing the allograft cartilage in a mixed liquid of chloroform and methanol for 6-24 hours; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1;

[0047] (2) adding the allogeneic cartilage treated in the above step (1) into the hydroc...

Embodiment 1

[0052] 1. Obtain non-autologous rib cartilage in a sterile environment; preferably take the eleventh or twelfth rib, clean it with distilled water and soak it;

[0053] 2. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0054] 3. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.5mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0055] 4. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-100 in the mixed solution of TritonX-100 and ammonia water is 1.5 %, the mass percentage of ammonia is 0.3%, and it is cleaned with distilled wat...

Embodiment 2

[0059] 1. Obtain non-autologous ear cartilage in a sterile environment; clean it with distilled water and soak it;

[0060] 2. Immerse the allogeneic cartilage in a mixed liquid of chloroform and methanol for 24 hours to degrease; wherein: the volume ratio of chloroform and methanol in the mixed liquid of chloroform and methanol is 1:1, and wash it with distilled water after taking it out;

[0061] 3. Immerse the degreased allograft cartilage in a hydrochloric acid solution with a concentration of 0.6mol / L, and keep stirring for 12 hours for decalcification, and wash it with distilled water after taking it out;

[0062] 4. Immerse the decalcified allogeneic cartilage in a mixed solution of TritonX-100 and ammonia water for 72 hours to deproteinize; wherein, the volume percentage of TritonX-100 in the mixed solution of TritonX-100 and ammonia water is 1 %, the mass percentage of ammonia is 0.3%, and it is cleaned with distilled water after taking it out;

[0063] 5. Place the ...

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Abstract

The invention relates to an allogenic decalcified bone material used for re-shaping and filling of the nose, and a preparation method thereof. The allogenic decalcified bone material comprises a nasal bone matrix prepared from allogenic decalcified bone. The nasal bone matrix comprises a nasal tip, a nasal columella and a nasal bridge, wherein the nasal bridge is connected with the nasal columella via the nasal tip; a narrowing transition section is arranged between the nasal bridge and the nasal tip, and the width of the transition section is smaller than the width of the nasal bridge; the lower part of the nasal bridge is composed of two V-shaped nasal bridge sections arranged in a cross manner; and the nasal bone of a human body is positioned between the two nasal bridge sections, so a prosthesis is prevented from displacement and wearing. The invention has the beneficial effects that through designing of the nasal bridge sections, the prosthesis closely contacts with the nasal bone and is prevented from displacement or wearing; and holes in the nasal bridge allow body fluids to flow into the holes and human tissue to grow into the holes, so a nose and the nasal prosthesis are integrated, movement, falling and festering of the nasal prosthesis are prevented, and postoperative pain in a patient is avoided. The preparation method is applicable to treatment of allogeneic bone.

Description

technical field [0001] The invention relates to the technical field of plastic surgery, in particular to a material for filling allogeneic decalcified bone in rhinoplasty and a preparation method thereof. Background technique [0002] Rhinoplasty (facelift) surgery is to change the height and shape of the nose by implanting appropriate materials so that it is in harmony with other parts of the face. It is the most common surgery in the field of plastic surgery. [0003] In medicine, there are many kinds of rhinoplasty materials, such as medical silicone rubber, autologous cartilage, animal tendon or ligament, expanded body (polytetrafluoroethylene), hyaluronic acid, etc. There are also many preparation methods for nasal bridge prosthesis. Among them, autologous cartilage is self-sourced, so there will be no rejection and no allergies, but it is difficult to shape during the production process. Animal tendons and ligaments are used as raw materials, because their composition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/56A61F2/18
CPCA61L27/3612A61L27/3687A61L27/3691A61L27/56A61F2/186A61L2430/02
Inventor 于浩
Owner 大连裕辰科技发展有限公司
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