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Nano carrier for near-infrared light triggered release of chemotherapy drug and preparation method thereof

A nano-carrier and chemotherapeutic drug technology, applied in the direction of nanotechnology, nanotechnology, nano-drugs, etc., can solve the problems of limited penetration ability, low efficiency, unsatisfactory effect, etc., and achieve the effect of overcoming the low release efficiency

Inactive Publication Date: 2017-03-22
INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tissue penetration of UV-visible light is very limited, and the same degradation reaction is produced by two-photon absorption of near-infrared light, but this method is very inefficient and the effect is not satisfactory.

Method used

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  • Nano carrier for near-infrared light triggered release of chemotherapy drug and preparation method thereof
  • Nano carrier for near-infrared light triggered release of chemotherapy drug and preparation method thereof
  • Nano carrier for near-infrared light triggered release of chemotherapy drug and preparation method thereof

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preparation example Construction

[0022] The invention provides a method for preparing a nano-carrier that triggers the release of chemotherapeutic drugs by near-infrared light, comprising: polymerizing a photosensitive monomer, a hydrophilic monomer and a hydrophobic monomer to obtain a photosensitive polymer; Up-converting nanoparticles, mixing the photosensitive polymer with the up-converting nanoparticles, adding water for ultrasonication, and then stirring, until the cyclohexane and chloroform are completely evaporated, and the photosensitive polymer acts on the upper Nanoparticles are converted to produce the nanocarriers.

[0023] Wherein, the photosensitive monomer can be diacrylic acid (1-nitro-2,5-benzhydryl alcohol) ester, and the photosensitive monomer can be synthesized from 2,5-dimethylnitrobenzene as an initial material through a one-step oxidation reaction ( KMnO 4 ,NaOH,H 2 O), one-step reduction reaction (BH 3 , tetrahydrofuran), and finally obtained by esterification of propylene. The hy...

Embodiment 1

[0035] 1) Add 292 mg of diacrylate (1-nitro-2,5-benzhydryl alcohol) ester, 272 microliters of dodecylamine and 500 mg of methoxypolyethylene glycol acrylate into a three-necked flask, and feed nitrogen gas for at least Exhaust the air for 20 minutes, melt and react at 100°C for 12 hours at a stirring speed of 1000 rpm, then add chloroform dropwise at a constant speed, and obtain a solution after the dropwise addition, then add ether to the obtained solution, and heat at 25°C After settling down for 3 hours, the product was filtered and vacuum-dried to obtain the photosensitive polymer LSP.

[0036] 2) The oleic acid complex of ytterbium (ytterbium oleate) and the oleic acid complex of thulium (thulium oleate) were synthesized in advance as precursor substances. Then, a mixture of ytterbium oleate (0.995 mmol), thulium oleate (0.005 mmol) and sodium fluoride (6 mmol) was added to a 50-mL solution containing 6 mL of oleic acid and 15 mL of 1-octadecene in a round-necked flask. ...

Embodiment 2

[0043] 1) Add 300 mg of (1-nitro-2,5-benzhydrylmethanol) diacrylate, 180 microliters of oleylamine and 500 mg of methoxypolyethylene glycol acrylate into a three-necked flask, and feed nitrogen gas for at least 20 Exhaust the air in minutes, melt and react at 90°C for 12 hours at a stirring speed of 1000 rpm, then add chloroform dropwise at a uniform speed, and obtain a solution after the dropwise addition, then add ether to the obtained solution, and heat at 25°C After settling for 3 hours, the product was filtered and vacuum-dried to obtain the photosensitive polymer LSP.

[0044] 2) The oleic acid complex of ytterbium (ytterbium oleate), the oleic acid complex of yttrium (yttrium oleate), and the oleic acid complex of thulium (thulium oleate) were synthesized in advance as precursor substances. Then, a mixture of ytterbium oleate (0.25 mmol), yttrium oleate (0.745 mmol) and thulium oleate (0.005 mmol) and sodium fluoride (6 mmol) was added to a tank containing 6 mL of oleic...

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Abstract

The invention provides a nano carrier for near-infrared light triggered release of a chemotherapy drug and a preparation method thereof. The preparation method comprises the steps: polymerizing a photosensitive monomer, a hydrophilic monomer and a hydrophobic monomer, to prepare a photosensitive polymer; providing oleic acid modified upconversion nanoparticles, mixing the photosensitive polymer with the upconversion nanoparticles, and allowing the photosensitive polymer to act on the upconversion nanoparticles, to prepare the nano carrier. The nano carrier for near-infrared light triggered release of the chemotherapy drug is composite upconversion nanoparticles having good hydrophilia, and has a structure with a single-layer shell wrapping multiple cores, so that the nanoparticles can quickly response to near-infrared light and accurately release the drug in vivo, and the problem of low release efficiency of general drug loaded nanoparticles is overcome.

Description

technical field [0001] The invention relates to a nano-carrier of chemotherapy drugs and a preparation method thereof, in particular to a nano-carrier of chemotherapy drugs triggered by near-infrared light and a preparation method thereof. Background technique [0002] Chemotherapy, which kills tumor cells with chemical drugs, has always been a major treatment method in cancer treatment. However, the current use of anticancer drugs lacks selectivity. become a bottleneck in the development of chemotherapy. Effective targeted drug delivery systems have become a breakthrough to solve the bottleneck of chemotherapy development, and drug carriers with stimuli-responsive properties have become a research hotspot in this field. [0003] Light-sensitive materials are a hot spot in the research of stimuli-responsive nanomaterials recently, mainly because light can provide some advantages that other stimuli do not have. Firstly, the wavelength and intensity of light can be controlle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/00A61K47/12A61K47/32B82Y5/00A61P35/00
Inventor 陈俊温凯凯胡毅
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
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