Composition for preventing and treating non-alcoholic fatty liver diseases

A non-alcoholic, disease-preventive technology, applied in the direction of drug combination, food science, plant raw materials, etc., can solve the problems of poor prognosis and failure to raise, and achieve the effect of improving liver weight increase

Inactive Publication Date: 2017-04-19
MUSHMED +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, if non-alcoholic fatty liver disease is left behind, non-alcoholic steatitis will progress to liver fibrosis or cirrhosis, and liver cancer will develop after cirrhosis, and the prognosis will be very bad.
[0007] In order to prevent non-alcoholic fatty liver disease, it is necessary to suppress the accumulation of fat in the liver, but so far, no good solution has been proposed other than reducing calorie intake and increasing calorie expenditure through exercise

Method used

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  • Composition for preventing and treating non-alcoholic fatty liver diseases
  • Composition for preventing and treating non-alcoholic fatty liver diseases
  • Composition for preventing and treating non-alcoholic fatty liver diseases

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0037] Preparation example: preparation of each extract

[0038] The pulp of aronia berries stored in the freezer is squeezed and extracted, and the sediment is removed to obtain a squeeze extract. The residue left after squeezing is mixed with 50% by weight of ethanol at a weight ratio of 1:2, and extracted at room temperature for 2 hours to obtain ethanol Extract. The mixture of the pressed extract and the ethanol extract was clarified with an Alfa-Laval disk separator, concentrated by distillation, and pulverized with a spray dryer to prepare an aronia extract.

[0039] In addition, dry seeds of milk thistle were put into ethanol whose relative weight was 2 times, extracted at room temperature for 6 hours, and then filtered to remove solid components. Afterwards, the milk thistle extract was prepared by powdering with a spray dryer.

[0040] Then, the dried fruiting body of Phellinus fungus was put into distilled water whose relative weight was 2 times, heated at 100° C. ...

Embodiment 1

[0041] Example 1: Induction of Fatty Liver Disease in Experimental Animals and Administration Composition

[0042] If experimental animals are fed with a high-fat diet for a long time, fat accumulation in the liver will be induced, resulting in fatty liver disease. Scientific opinion (Journal of Hepatology (2011), doi:10.1016 / j.jhep, 2010.08.19). Therefore, using the above model, it was demonstrated that the above composition is effective for non-alcoholic fatty liver disease.

[0043] Five-week-old C57BL / 6-line male mice were used in experiments after acclimatization for one week in an environment where room temperature and humidity can be adjusted and kept constant.

[0044] The normal control group (NC group) was fed with common feed (containing 12Kcal% of crude fat), and 0.1 ml of distilled water was orally administered once a day from start to finish.

[0045] In order to induce fatty liver in the high-fat diet group, the experimental animals were fed with high-fat diet...

Embodiment 2

[0048] Embodiment 2: Gross and pathological examination of the liver

[0049] After 12 weeks of the experiment, the macroscopic and histological changes of the liver removed from the experimental animals were as follows: figure 1 shown.

[0050] It can be observed that the liver of the high-fat diet control group (HFC) is larger than that of the normal control group (NC) and turns yellow, but in the mixed composition of aronia extract, milk thistle extract and Phellinus extract Liver hypertrophy and discoloration were not observed in the liver of the (APS) administration group.

[0051] Moreover, as a result of staining the fat accumulated in the liver cells with the Oil Red O method, there were no fat vesicles in the liver cells of the NC group, but red stained fat vesicles appeared in the liver of the HFC group. Hepatocytes filled with giant fat vesicles existed in groups centered on venules. However, only tiny fat vesicles stained red were observed in the hepatocytes of ...

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Abstract

The present invention relates to a composition useful in the prevention and treatment of non-alcoholic fatty liver diseases caused by fat accumulated in the liver due to excessive nutrient ingestion or metabolic syndrome, regardless of alcohol consumption. The composition of the present invention can significantly improve the increased liver weight, accumulated liver triglycerides, increased serum ALT level, reduced liver SOD activity, and reduced liver total antioxidative capacity in experimental animals raised with a high-fat diet for a long period of time. Since the fatty liver diseases induced by the high-fat diet in the experimental animals shows similar pathological and immunological findings to human non-alcoholic fatty liver diseases, the composition of the present invention can be provided as an excellent pharmaceutical preparation or health supplement food used in the prevention and treatment of non-alcoholic fatty liver diseases.

Description

technical field [0001] The present invention relates to a composition effective for the prevention and treatment of non-alcoholic fatty liver disease caused by fat accumulation in the liver unrelated to alcohol intake and caused by excessive nutritional intake or metabolic syndrome. [0002] This application claims priority based on Korean Patent Application No. 10-2014-0070363 filed on June 10, 2014, and all the contents disclosed in the specification and drawings of the application are incorporated herein by reference. Background technique [0003] Fatty liver disease is a disease in which fat accumulates in the liver. It is divided into alcoholic fatty liver disease caused by excessive alcohol intake and non-alcoholic fatty liver disease unrelated to alcohol intake. Nonalcoholic fatty liver disease includes nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. [0004] Nonalcoholic fatty liver disease is divided into macrovesicular fatty liver disease and mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K36/28A61K36/07A61P1/16
CPCA61K36/07A61K36/28A23L33/105A61K36/73A61P1/16A61K2300/00A23V2002/00
Inventor 朴炯镇张奉根
Owner MUSHMED
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