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Traditional Chinese medicinal compound extract used for assisting memory improvement and preparation method of traditional Chinese medicinal compound extract

A technology that assists in improving memory and extracts, and is applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2017-04-26
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are already 29 kinds of health care products made of maca in China, but the health effects are all to relieve physical fatigue. Up to now, there is no health care product made of maca as raw material to help improve memory

Method used

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  • Traditional Chinese medicinal compound extract used for assisting memory improvement and preparation method of traditional Chinese medicinal compound extract
  • Traditional Chinese medicinal compound extract used for assisting memory improvement and preparation method of traditional Chinese medicinal compound extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Maca 20g Polygala 40g Sour date kernel 40g

[0027] 1. Extraction: After pulverizing the prescription amount of three flavor medicinal materials, add 70% ethanol for reflux extraction for 3 times, each time the amount of 70% ethanol used is 12 times the total dry weight of the three flavor medicinal materials, and extract 2 hours each time, combine the extracts, filter, and reduce the filtrate Press and concentrate to flow extract paste.

[0028] 2. Purification by macroporous resin adsorption chromatography: Dissolve the extract in 1 with water and filter, and pass the filtrate through the treated D 101 Type macroporous adsorption resin, gradient elution with water and 30%, 50%, 70%, 95% ethanol, HPLC detection, collect the fractions rich in Polygala saponins and jujuboside compounds, combine, concentrate under reduced pressure, and freeze The compound extract is obtained by drying.

Embodiment 2

[0030] Maca 20g Polygala 60g Sour date kernel 40g

[0031] 1. Extraction: After pulverizing the prescription amount of three flavor medicinal materials, add 60% ethanol for reflux extraction 3 times, each time using 60% ethanol is 10 times the total dry weight of the three flavor medicinal materials, and extract 1.5h each time, combine the extracts, filter, and filtrate Concentrate under reduced pressure to a liquid extract.

[0032] 2. Purification by macroporous resin adsorption chromatography: Dissolve the extract in 1 with water and filter, and pass the filtrate through the treated HPD-100 macroporous adsorption resin with water and 30%, 50%, 70%, 95% ethanol Gradient elution, HPLC detection, collect the fractions rich in Polygala saponins and jujube saponins, combine, concentrate under reduced pressure, and freeze-dry to obtain the compound extract.

Embodiment 3

[0034] Maca 10g Polygala 70g Sour date kernel 40g

[0035] 1. Extraction: After the prescription amount of Shawei medicinal materials is crushed, add 50% ethanol for reflux extraction twice. The amount of 50% ethanol used each time is 12 times the dry weight of the shamisen medicinal materials, and the extraction time is 1 hour each time. The extracts were combined, filtered, and the filtrate was concentrated under reduced pressure to a liquid extract.

[0036] 2. Macroporous resin adsorption chromatographic purification: Dissolve the extract in 1 with water and filter, and the filtrate is passed through the treated AB-8 type macroporous adsorption resin with water and 30%, 50%, 70%, 95% ethanol Gradient elution, HPLC detection, collect the fractions rich in Polygala saponins and jujube saponins, combine, concentrate under reduced pressure, and freeze-dry to obtain the compound extract.

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PUM

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Abstract

The invention relates to a traditional Chinese medicinal compound extract used for assisting memory improvement and a preparation method of the traditional Chinese medicinal compound extract. The traditional Chinese medicinal compound extract is prepared from maca, radix polygalae and spina date seeds. The traditional Chinese medicinal compound extract has the efficacies of tonifying the kidney and boosting the essence, and tranquilizing the mind by nourishing the heart. The research results of the step-down test and the dark avoidance test in the mouse memory acquisition disturbance model induced by scopolamine show that the extract has the function of improving the memory.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine compound extract prepared with maca, polygala, and wild jujube kernels as raw materials for assisting in improving memory and a preparation method of the extract. Background technique [0002] In recent years, the number of elderly people in my country has been increasing year by year, and the incidence of diseases related to the decline of learning and memory ability of the elderly has been increasing year by year. Amnesia is a common and multiple disease in the elderly. In particular, amnesia caused by insufficient blood supply to the brain is the most common, and the main manifestation of amnesia is the decline in the ability of human brain learning and memory. Many middle-aged and elderly people and their family members are suffering from memory loss caused by cerebral ischemia, and at the same time it is also a huge economic burde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61P25/00
CPCA61K36/31A61K36/69A61K36/725A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 王芳郭琪梁大连刘玉黔于亮
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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