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Superabsorbent medical composite haemostasis sponge and preparation method thereof

A hemostatic sponge and super-absorbent technology, applied in the field of medical materials, to achieve the effects of strong liquid absorption capacity, high liquid absorption rate, and good application value

Inactive Publication Date: 2017-04-26
苏州纳贝通环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the actual hemostatic effect and mechanical strength of the existing hemostatic sponges need to be further improved.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of a superabsorbent medical composite hemostatic sponge, the preparation method comprising the following steps:

[0020] (1) By weight, weigh raw materials: 19 parts of alginate, 10 parts of fibrin glue, 5 parts of cross-linked dextran gel, 3 parts of polyuronic acid hemicellulose, 4 parts of hyaluronan, 1 part of strontium gluconate, 0.5 parts of iron dextran, 1.2 parts of epigallocatechin, 0.8 parts of 5-methoxy-N,N-diisopropyltryptamine, 0.6 parts of menthanediamine, 0.4 parts of eucalyptol, 0.8 part of puffball powder, 0.5 part of cross-linking agent, 1.5 parts of Tween-60, 25 parts of ethanol, 60 parts of distilled water; The cross-linking agent is citric acid, bis A mixture of sodium acetate, ferric chloride, polyvinyl alcohol and sodium trimetaphosphate; the alginate is sodium alginate;

[0021] (2) Add alginate and fibrin glue into distilled water, mix well, adjust the pH of the solution to 8, then heat and stir for 20 minutes, then add puf...

Embodiment 2

[0026] A preparation method of a superabsorbent medical composite hemostatic sponge, the preparation method comprising the following steps:

[0027] (1) By weight, weigh raw materials: 28 parts of alginate, 21 parts of fibrin glue, 12 parts of cross-linked dextran gel, 9 parts of polyuronic acid hemicellulose, 8 parts of hyaluronan, 4 parts of strontium gluconate, 2 parts of iron dextran, 3.6 parts of epigallocatechin, 2.4 parts of 5-methoxy-N,N-diisopropyltryptamine, 1.8 parts of menthane diamine, 1.3 parts of eucalyptol, 2 parts of puffball powder, 2.6 parts of cross-linking agent, 3 parts of Tween-60, 38 parts of ethanol, 80 parts of distilled water; A mixture of sodium acetate, ferric chloride, polyvinyl alcohol and sodium trimetaphosphate; the alginate is ammonium alginate;

[0028] (2) Add alginate and fibrin glue into distilled water, mix well, adjust the pH of the solution to 10, then heat and stir for 60 minutes, then add puffball powder, iron dextran and strontium g...

Embodiment 3

[0033] A preparation method of a superabsorbent medical composite hemostatic sponge, the preparation method comprising the following steps:

[0034] (1) By weight, weigh raw materials: 21 parts of alginate, 11 parts of fibrin glue, 5.7 parts of cross-linked dextran gel, 3.4 parts of polyuronic acid hemicellulose, 4.5 parts of hyaluronan, 1.6 parts of strontium gluconate, 0.7 parts of iron dextran, 1.4 parts of epigallocatechin, 0.9 parts of 5-methoxy-N,N-diisopropyltryptamine, 0.8 parts of menthane diamine, 0.6 parts of eucalyptol, 1.1 parts of puffball powder, 0.7 parts of cross-linking agent, 1.7 parts of Tween-60, 28 parts of ethanol, 64 parts of distilled water; A mixture of sodium acetate, ferric chloride, polyvinyl alcohol and sodium trimetaphosphate; the alginate is potassium alginate;

[0035] (2) Add alginate and fibrin glue into distilled water, mix well, adjust the pH of the solution to 9, then heat and stir for 40 minutes, then add puffball powder, iron dextran an...

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Abstract

The invention discloses a superabsorbent medical composite haemostasis sponge and a preparation method thereof. The haemostasis sponge comprises the raw materials: alginate, fibrin glue, sephadex gel, polyuronide hemicelluloses, hyaluronan, gluconic acid strontium, iron-dextrin, epigallocatechin, 5-methoxy-N,N-diisopropyltryptamine, mint alkyl diamine, eucalyptole, puffball powder, a cross-linking agent, tween-60, ethanol 2, and distilled water. The liquid absorbing capability of the medical composite haemostasis sponge is strong, haemostasis time is short, effect is good, invasion of an extraneous substance can be isolated, wound healing is promoted, and the superabsorbent medical composite haemostasis sponge can be widely used for haemostasis and restoration of burn, wound, and surgical operation wound, and has good application value.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a superabsorbent medical composite hemostatic sponge and a preparation method thereof. Background technique [0002] Hemostasis is a complex process. In addition to blood coagulation itself, external pressure and other hemostatic factors can also shorten the hemostasis time and promote wound healing. A good medical hemostatic material not only needs to have the usual characteristics of short hemostatic time, good hemostatic effect, and no increase in wound infection, but also should not cause secondary trauma. It should also have good biocompatibility for implanted materials in the body and have no antigens. It is non-toxic, degradable, has good adhesion to tissues, and has good compatibility with wounds and wound sites. It also has multiple functions such as repair and treatment. Now common hemostatic materials mainly include: hemostatic sponge, hemostatic...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/00A61L26/00
CPCA61L24/08A61L24/0005A61L24/0015A61L24/0036A61L24/106A61L26/0023A61L26/0042A61L26/0057A61L26/0066A61L26/0085A61L2300/30A61L2300/418A61L2400/04
Inventor 潘明华
Owner 苏州纳贝通环境科技有限公司
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