L-arginine alpha-ketoisocaproate preparation method

Abstract

The invention relates to a L-arginine alpha-ketoisocaproate preparation method. The method comprises the following steps: accurately weighing 100 g of keto isocaproic acid, placing the material in a 1000 ml of flask, adding 600 ml of water, heating the material to the temperature of 60-70 DEG C, gradually adding L-arginine, adjusting a solution to neutrality, adding 10 g of active carbon, stirring the material for1 hour at the temperature of 60-70 DEG C, filtering the material while hot, collecting a filtrate; turning on a high-speed centrifuging and spraying drier for heating the material, setting the air intake temperature at 130-135 DEG C, adding the prepared filtrate in a solution pot, controlling the flow velocity of a charge pump at 5-10 ml / min, and collecting the material after centrifugal spray drying to a granular state at a discharge hatch, and obtaining the 160 g of white powder L-arginine alpha-ketoisocaproate. The method has the advantages of simple production step, and convenient and practical performances.

Description

technical field [0001] The invention relates to a preparation method of L-arginine α-ketoisocaproate. Background technique [0002] The structural formula of L-arginine a-ketoisocaproate is: [0003] [0004] Molecular formula: C 18 h 34 N 4 o 8 ; Molecular weight: 434.5; [0005] Properties: white crystalline powder. [0006] At present, the production method of this product in China is to mix a-ketoisocaproic acid and an appropriate amount of absolute ethanol, heat it to a suitable temperature, slowly add L-arginine, adjust to neutrality, and slowly dissolve the reaction solution. Add it to a large amount of anhydrous ethyl acetate at a suitable temperature. After strong and rapid stirring for a long time, the material gradually solidifies and crystallizes, and then cools down, filters and dries to obtain the finished product. [0007] The defect of this method is that because of the strong hygroscopicity of L-arginine α-ketoisocaproate, if there is a very small ...

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Problems solved by technology

[0007] The defect of this method is that because of the strong hygroscopicity of L-arginine α-ketoisocaproate, if there is a very small amount of water in the solvent or reaction system, well-solidified crystals cannot be obtained, and the material is extremely fluid. Poor jelly, so the requirements for the solvent and reaction system used are very high. In addition, because ethanol and a large amount of ethyl acetate are used, the filtrate after filtration is a mixture of ethanol and ethyl acetate, which needs to be diluted with a large amount of water. Dissolving ethanol into water to achieve the purpose of separation from ethyl acetate, the recovered solvent cannot be applied to the production of this product, and the total cost is very high.

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