Application of mir-342-5p in the preparation of drugs for preventing and treating heart disease
A drug and applied technology, applied in the field of biomedicine, can solve the problems of poor efficacy in patients with myocardial insulin resistance, achieve the effects of reducing myocardial ischemia/reperfusion injury, improving cardiac function, and significant cardioprotection
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[0026] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.
[0027] miR-342-5p is a kind of miRNA whose sequence is: GAGUUAGUGUCUAUCGUGGGGA. The present invention finds that miR-342-5p has a significant cardioprotective effect through the following research and can reduce myocardial ischemia / reperfusion injury, which can be applied to prevent and treat heart disease medicine.
[0028] 1) Inhibition of miR-342-5p on cardiac ischemia / reperfusion (I / R) injury in vivo
[0029] The 6-week-old male SD rats were randomly divided into two groups, the experimental group (I / R+miR-342-5p) was injected with miR-342-5p agomir (10nmol) at the myocardial point, and the control group (I / R) was injected with the myocardial point its contrast reagent. After 48 hours, the myocardial ischemia-reperfusion model was established. Under the condition of 3% pentobarbital so...
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