Solid preparation fabrication equipment and method

A technology for solid preparations and manufacturing equipment, which is applied in the direction of drying solid materials, lighting and heating equipment, and drying solid materials without heating, which can solve the problems of cumbersome processing, time-consuming and energy-consuming, and the influence of heat-sensitive substances

Inactive Publication Date: 2017-05-24
SHANGHAI TOFFLON SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to develop a solid preparation with high production efficiency and suitable for heat-sensitive substances in view of the defects of the current tablet and capsule pretreatment process that are cumbersome, have an impact on heat-sensitive substances, and consume time and energy in conventional freeze-drying. equipment and methods

Method used

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  • Solid preparation fabrication equipment and method
  • Solid preparation fabrication equipment and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] A solid preparation manufacturing equipment consists of a batch vacuum spray freeze-drying device, a mixing device and a solid preparation molding device. The solid preparation molding device is a tablet press.

[0095] Such as figure 1 As shown, the batch-type vacuum spray freeze-drying device includes: a closed container 1 for holding materials during the vacuum spray freeze-drying process; The atomizing nozzle 2 in the container 1 described above; used to form a vacuum environment in the container 1 during the vacuum spray freezing granulation stage to vaporize the ethanol in the droplets and absorb heat so that the droplets are cooled and frozen to form particles, and The drying stage is continuously vacuumed to maintain the vacuum system of the vacuum environment; and the vacuum system used for refrigeration in the vacuum spray freeze granulation stage to avoid melting of the ethanol in the granules and to provide the ethanol in the granules in the drying stage ...

Embodiment 2

[0109] A solid preparation manufacturing equipment is composed of a batch type vacuum spray freeze drying device and a solid preparation molding device. The solid preparation forming device is a capsule filling machine ( Capsule filling machine brand: Fuchang; model: 120C ).

[0110] Such as figure 2 As shown, the batch-type vacuum spray freeze-drying device includes: a closed container 1 for holding materials during the vacuum spray freeze-drying process; The atomizing nozzle 2 in the container 1 described above; used to form a vacuum environment in the container 1 during the vacuum spray freezing granulation stage to vaporize the water in the droplets and absorb heat so that the droplets are cooled and frozen to form particles, and The drying stage is continuously vacuumed to maintain the vacuum system of the vacuum environment; and it is used for refrigeration in the vacuum spray freeze granulation stage to prevent the water in the particles from melting and to provide...

Embodiment 3

[0122] A solid preparation manufacturing equipment is composed of a continuous vacuum spray freeze-drying device, a mixing device and a solid preparation molding device. The solid preparation forming device is a capsule filling machine ( Capsule filling machine brand: Future; Model: 120C ).

[0123] Such as image 3 As shown, the continuous vacuum spray freeze-drying device includes a vacuum spray freeze-drying device 100, a dynamic heating and drying device 200, and a vacuum discharge mechanism 300 connected in sequence to form a closed container.

[0124] to combine Figure 4 , the vacuum spray freezing granulation device 100 includes a spray cylinder 1-1 for containing the product in the spray granulation process; a plurality of spray cylinders 1-1 for atomizing and dispersing the liquid to be freeze-dried into droplets and spraying them into the spray cylinder 1-1 Atomizing nozzle 1-2; a vacuum system for forming a vacuum environment in a closed container so that par...

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PUM

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Abstract

The invention provides solid preparation fabrication equipment and method. The solid preparation fabrication equipment is characterized by comprising a spray freeze-drying device and a solid preparation forming device. The solid preparation fabrication method includes the steps that a solution, mixed suspension liquid or emulsion containing medicine effective ingredients is prepared, spray freezing and drying are performed through the spray freeze-drying device under the stirring or non-stirring state, particles obtained through spray freezing and drying are directly fabricated into a solid preparation through the solid preparation forming device, or the particles obtained through spray freezing and drying are mixed with at least one accessory and then fabricated into the solid preparation through the solid preparation forming device. The solid preparation fabrication equipment and method are particularly suitable for but not limited to the production or research process of materials of properties of sensitization, low content proportion, biological activity, heat sensitivity and the like.

Description

technical field [0001] The invention relates to a solid preparation manufacturing equipment and method. Background technique [0002] In general, the production / development process of tablets or capsules generally has pretreatment processes such as granulation, granulation, drying, and mixing. This process has its inherent disadvantages, such as time-consuming, uneven mixing, heat sensitivity The impact of the substance is relatively large, and it is easy to fly dust. For the pre-treatment of allergenic substances, factors such as airtightness and cleanability of each link also need to be considered, which will increase additional cost input. [0003] There are many granulation methods commonly used at present, including high-shear wet granulation, fluidized bed granulation, dry granulation, spray drying granulation, etc., but all methods (except dry granulation) require heated It has a greater impact on heat-sensitive substances, and spray drying is prone to sticking to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F26B5/06A61J3/10A61J3/07B01J2/02
CPCF26B5/06
Inventor 郑效东
Owner SHANGHAI TOFFLON SCI & TECH CO LTD
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