A kind of preparation method and application of protein-coated metal sulfide nanoparticles
A metal sulfide and nanoparticle technology, which is applied in the direction of non-active components of polymer compounds, wave energy or particle radiation treatment materials, medical preparations containing active components, etc., can solve the problems of poor operation feasibility, harsh conditions, water solubility and Poor biological description and other problems, to achieve good photothermal properties, mild conditions, and meet the effects of green environmental protection
Inactive Publication Date: 2020-06-09
CENT SOUTH UNIV
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Problems solved by technology
[0004] In order to solve the problems of harsh conditions, poor operational feasibility, poor water solubility and biodegradability in the synthesis process of existing metal sulfides, the purpose of the present invention is to provide a protein-coated method with mild reaction conditions, simple operation and low cost. A method of metal sulfide nanoparticles, the protein-coated metal sulfide nanoparticles prepared by this method have water solubility, good biodegradability and high photothermal efficiency, which is conducive to wide application
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Embodiment 1
[0045] Step (1) Preparation of BSA-coated CuS nanoparticles:
[0046] Under stirring at 50°C, 250 μL of BSA (250 mg / mL), 20 μL of Cu(NO 3 ) 2 (50mmol·L -1 , dissolved in 1mol L -1 HNO 3 middle), adding 600 μL of water, and then adding NaOH solution for 30 min.
[0047] Depend on figure 1 It can be seen that step (1) presents a black solution with strong near-infrared absorption, showing the Tyndall effect.
[0048] Depend on figure 2 It can be seen that the atomic ratio of Cu / S obtained in step (1) is 3:2, further confirming that CuS and Cu 2 the existence of S.
[0049] Depend on image 3 It can be seen that the BSA coated Cu obtained in step (1) 2-X S nanoparticles are spherical with an average size of 5.0 ± 2.0 nm; BSA coated Cu 2-X S nanoparticles exhibit different contrast between central and edge regions; metal-containing particles are generally brighter than non-metallic particles, so it can be inferred that Cu 2-X The surface of S is coated with a protein ...
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Abstract
The invention discloses a preparation method of a protein-coated metal sulfide nanoparticle and application thereof. The preparation method comprises the following step of in an alkaline solution, enabling protein to react with metal ions under the catalyzing action of metal ions, so as to generate the protein-coated metal sulfide nanoparticle. The preparation method has the advantages that the preparation method is simple, the condition is mild, and the cost is low. The prepared protein-coated metal sulfide nanoparticle has the advantages that the water dissolvability is good, the biocompatibility is good, the in-vitro permeability and anti-tumor activity are realized, and the like; the broad application prospect is realized in the fields of tumor photo-thermal therapy or photo power therapy and the like.
Description
technical field [0001] The invention relates to a preparation method of metal sulfide nanoparticles, in particular to a method of directly converting metal ions and proteins into protein-coated metal sulfide nanoparticles with water solubility and biocompatibility under the trigger of alkali, belonging to The field of biomedical material preparation. Background technique [0002] In recent decades, due to the unique properties of metal sulfide semiconductor nanomaterials in optics, electronics and magnetic fields, their role in the diagnosis and treatment of diseases has increasingly attracted great interest of scientific researchers. In particular, metal sulfide nanoparticles have received special attention because they are more easily recognized and cleared in vivo. Therefore, metal sulfide nanoparticles have better biosafety. Metal sulfides such as Ag 2 S, CdS, ZnS, and PbS have been widely used in optical imaging and biomarkers. Bi 2 S 3 , CuS, MoS 2 , FeS 2 、WS ...
Claims
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IPC IPC(8): A61K41/00A61K9/51A61K47/42A61P35/00
CPCA61K9/5169A61K41/0052A61K41/0057
Inventor 刘又年宋亚伟盛剑平王立强邓留阳明辉
Owner CENT SOUTH UNIV