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A low-temperature injectable acrylic resin bone cement and its preparation method

A technology of acrylic resin and bone cement, which can be used in pharmaceutical formulations, prostheses, and drug delivery. It can solve problems such as changes and lower maximum temperatures, achieve lower exothermic temperatures, lower monomer residues, and improve thermal burns. Effect

Active Publication Date: 2019-10-25
NINGBO HICREN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, German Patent 3245956A1 discloses a bone cement based on liquid monomers and powdery polymerized acrylates and / or methacrylates, catalysts and accelerators. Surface active liquid can effectively reduce the heat released during bone cement polymerization, but the final product introduces surface active liquid, which limits clinical application; Chinese patent 104784753A discloses a composite bone cement that can reduce thermal necrosis effect, the bone cement powder A phase-change microcapsule material (PCM) was added to reduce the maximum temperature during curing, making it significantly lower than the clinical application requirements. Although it can reduce thermal necrosis, the final product has changed, and clinical application needs further verification.

Method used

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  • A low-temperature injectable acrylic resin bone cement and its preparation method
  • A low-temperature injectable acrylic resin bone cement and its preparation method
  • A low-temperature injectable acrylic resin bone cement and its preparation method

Examples

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Effect test

Embodiment 1

[0046] A preparation method of low-temperature injectable acrylic resin bone cement, comprising the following steps:

[0047] (1) Preparation of Component A

[0048] a. adopting the suspension polymerization method to prepare polymethyl methacrylate with a particle size range of 60-120 μm and a styrene-methyl methacrylate copolymer with a particle size range of 80-150 μm;

[0049] b. In terms of mass percentage, the polymethyl methacrylate prepared in 50wt% step a, the styrene-methyl methacrylate copolymer prepared in 25wt% step a, the tertiary benzoyl peroxide of 0.8wt% Butyl ester and 24.2wt% of barium sulfate with a particle size range of 30-50 μm are uniformly mixed to obtain component A;

[0050] (2) Preparation of liquid phase

[0051] c. In terms of volume percentage, mix 99vol% methyl acrylate and 1vol% N-N-dimethyl-p-toluidine evenly, and then add 20ppm hydroquinone to obtain a liquid phase;

[0052] (3) Preparation of Component B

[0053] d. Prepare polymethyl me...

Embodiment 2

[0068] A preparation method of low-temperature injectable acrylic resin bone cement, comprising the following steps:

[0069] (1) Preparation of Component A

[0070] a. adopting the suspension polymerization method to prepare polymethyl methacrylate with a particle size range of 20-100 μm and a styrene-methyl methacrylate copolymer with a particle size range of 100-200 μm;

[0071] b. In terms of mass percentage, the polymethyl methacrylate prepared in 30wt% step a, the styrene-methyl methacrylate copolymer prepared in 29.5wt% step a, the tertiary benzoyl peroxide of 2wt% Butyl ester and 38.5wt% of barium sulfate with a particle size range of 1-20 μm are uniformly mixed to obtain component A;

[0072] (2) Preparation of liquid phase

[0073] c. In terms of volume percentage, mix 95vol% butyl methacrylate and 5vol% N-N-dimethyl-p-toluidine evenly, and then add 80ppm hydroquinone monomethyl ether to obtain a liquid phase;

[0074] (3) Preparation of Component B

[0075] d. P...

Embodiment 3

[0081] A preparation method of low-temperature injectable acrylic resin bone cement, comprising the following steps:

[0082] Preparation of Component A

[0083] a. adopting the suspension polymerization method to prepare polymethyl methacrylate with a particle size range of 20-80 μm and a methyl acrylate-methyl methacrylate copolymer with a particle size range of 80-150 μm;

[0084] b. In terms of mass percentage, the polymethyl methacrylate prepared in 45wt% step a, the methyl acrylate-methyl methacrylate copolymer prepared in 44wt% step a, the tertiary benzoyl peroxide Component A is obtained by uniformly mixing butyl ester and 10 wt% of zirconia with a particle size range of 10-30 μm;

[0085] (2) Preparation of liquid phase

[0086] c. In terms of volume percentage, mix 98vol% methyl acrylate and 2vol% N-N-dimethyl-p-toluidine evenly, and then add 60ppm hydroquinone to obtain a liquid phase;

[0087] (3) Preparation of Component B

[0088] d. Prepare polymethyl methacry...

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Abstract

The invention relates to low-temperature injectable acrylic resin bone cement and a preparation method thereof. The low-temperature injectable acrylic resin bone cement comprises a solid phase and a liquid phase, wherein the solid-liquid ratio of the solid phase to the liquid phase is 0.25-0.5mL / g, the solid phase comprises, by mass percentage, 25-80wt% of component A and 20-75wt% of component B, the component A comprises 59.5-99.5wt% of powdered acrylate polymer and 0.5-2wt% of peroxide initiator, and the component B comprises granular acrylate polymer; the liquid phase comprises, by volume percentage, 95-99.9vol% of acrylate monomer and 0.1-5vol% of accelerant. The low-temperature injectable acrylic resin bone cement has the advantages that the low-temperature injectable acrylic resin bone cement is low in heat discharge temperature during curing, and after the curing, new products are not introduced and few monomer residues and good biocompatibility are achieved.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a low-temperature injectable acrylic resin bone cement and a preparation method thereof. Background technique [0002] Osteoporosis is one of the most common bone diseases in middle-aged and elderly people. The number of osteoporosis patients in my country is close to 100 million, and at least 210 million people have lower bone mass than normal, which is the country with the largest number and potential number of osteoporosis patients. A set of data published by the International Osteoporosis Foundation shows that an osteoporotic fracture occurs every 3 seconds in the world, 1 / 3 of women and 1 / 5 of men will suffer a fracture after the age of 50, 20% 100% of hip fracture patients die within 6 months of fracture, and half of patients are unable to take care of themselves. Injecting bone cement into injured bones or vertebrae is a relatively simple and effective method for trea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/02A61L27/50
CPCA61L27/025A61L27/16A61L27/50A61L2400/06A61L2430/02C08L33/10C08L33/08
Inventor 卓清山张鹏云汪宇吕世文
Owner NINGBO HICREN BIOTECH
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