Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A graphene oxide/molecularly imprinted filter membrane for detecting propranolol and its preparation and application

A molecular imprinting and graphene technology, applied in the field of materials, can solve the problems of cumbersome processing, difficult detection, and long measurement cycle.

Active Publication Date: 2019-11-05
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For propranolol, currently commonly used detection methods include high performance liquid chromatography, gas chromatography-mass spectrometry, etc. These methods generally have the disadvantages of cumbersome processing, long measurement cycle, expensive instruments, etc., and it is difficult to quickly detect and monitor pollution changes in real time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A graphene oxide/molecularly imprinted filter membrane for detecting propranolol and its preparation and application
  • A graphene oxide/molecularly imprinted filter membrane for detecting propranolol and its preparation and application
  • A graphene oxide/molecularly imprinted filter membrane for detecting propranolol and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0151] The present invention also provides a preparation method of the graphene oxide / molecularly imprinted filter membrane, comprising the steps of:

[0152] i) providing a molecularly imprinted prepolymerization solution, a dispersion of graphene oxide, a filter membrane as a substrate, a solution containing imprinted molecules, and an eluent for eluting imprinted molecules;

[0153] ii) uniformly dispersing the dispersion of the graphene oxide on the surface of the filter membrane, suction filtering and optionally drying to obtain a graphene oxide filter membrane;

[0154] iii) immersing the graphene oxide filter membrane in the molecularly imprinted prepolymerization solution, adding a solution containing imprinted molecules, and reacting the resulting mixed solution under a nitrogen atmosphere;

[0155] iv) optionally washing and drying the product obtained in the preceding steps with solvent A;

[0156] v) placing the product obtained in the preceding steps in the eluen...

Embodiment 1

[0170] Example 1 Preparation of Graphene Oxide / Molecularly Imprinted Filter Membrane 1

[0171] 1) First, dissolve 50mL of 0.2M methyl methacrylate in 50mL of methanol solution, and stir evenly for 10min. During the stirring process, slowly add 0.4g of azobisisobutyronitrile and 20mL of ethylene glycol dimethyl acrylate, and continue to stir for 10 minutes to obtain molecularly imprinted prepolymer solution 1.

[0172] 2) Using a nitrocellulose filter as a substrate, 3 mL of graphene oxide dispersion (solid content 2%, specific surface area of ​​graphene oxide 200 m 2 / g) uniformly dispersed on the filter membrane, dried overnight in the air after vacuum filtration on the filter to obtain a graphene oxide filter membrane 1, which should be cleaned with deionized water before each use.

[0173] 3) Soak the graphene oxide filter membrane 1 prepared in step 2) in the 120mL molecularly imprinted pre-polymerization liquid prepared in step 1, after standing for 30min, add 20mL of pro...

Embodiment 2

[0179] Embodiment 2 detects propranolol

[0180] Preparation of Ag nanoparticles

[0181] 20mL silver nitrate solution (10 -2 M), 20mL mass fraction of 1% trisodium citrate solution and 80mL deionized water mix uniformly, add 100mL freshly prepared sodium borohydride solution (10 mL) under strong stirring conditions -2 M), continue to react at room temperature for 1 h to obtain a yellow-green spherical Ag nanoparticle sol with a particle size of 40-70 nm.

[0182] Graphene oxide / molecularly imprinted filter membrane 1+Ag nanoparticles for detection of propranolol

[0183] Put the graphene oxide / molecularly imprinted filter membrane 1 into the syringe filter; draw 2mL, 10 -7 M propranolol solution, put on a syringe filter and inject and filter the propranolol solution; then remove the syringe filter, add 0.5mL of the spherical Ag nanoparticles prepared by the above steps dropwise on it, and perform Raman spectroscopy detection, get the enhanced Raman spectrum, see Figure ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
specific surface areaaaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a graphene oxide / molecular imprinting filtering membrane for detecting propranolol, as well as a preparation and an application thereof. Specifically, the invention discloses a method for detecting propranolol in a detected sample by adopting the graphene oxide / molecular imprinting filtering membrane and a metallic nanometer grain combined raman technique. The detection method has the advantages of high sensitivity, simple and convenient operation, less time consumption, low cost, and the like.

Description

technical field [0001] The invention relates to the field of materials, in particular to a graphene oxide / molecularly imprinted filter membrane for detecting propranolol and its preparation and application. Background technique [0002] Propranolol is one of the most commonly used beta adrenergic blockers for the treatment of arrhythmia, angina pectoris, high blood pressure and other diseases. After taking or injecting, most of it is digested in the human body, but a small part is still discharged into the environment. With the increase of usage, more and more rivers and lakes have found the existence of propranolol. When propranolol enters the human body, it can completely inhibit heart function, induce and aggravate bronchial asthma, and cause adverse reactions such as intermittent claudication. [0003] For propranolol, currently commonly used detection methods include high performance liquid chromatography, gas chromatography-mass spectrometry, etc. These methods genera...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 程昱川刘雅娇鲍静静张磊许高杰
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com