A kind of preparation method of electrospray needle
An electrospray and capillary technology, applied in the fields of analytical chemistry and proteomics, can solve the problems of no control measures for the needle diameter, difficulty in ensuring that the inner wall is not corroded, and cumbersome and complicated operation process, so as to achieve smooth inner wall and easy screening performance , The effect of simple operation process
Active Publication Date: 2018-07-06
SINOMS BIOTECH CO LTD
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Problems solved by technology
[0004] At present, there is no control measure for the diameter of the needle in the commercially available electrospray needle preparation equipment, and the operation process of controlling the inner diameter of the needle by chemical etching is relatively cumbersome and complicated. The outer wall of the obtained needle is not smooth, and it is difficult to ensure the inner wall not corroded at all
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[0032] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.
[0033] Such as figure 1 Shown is a schematic diagram of the operation of the method for preparing an electrospray needle with an adjustable coaxial diameter according to the present invention, which includes a wire 1, a capillary 2 (quartz capillary is preferred in the present invention) and a heat source 3. The preparation method of the electrospray spray needle of the present invention, the method comprises the following steps:
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The invention discloses a method for preparing an electro-spraying nozzle needle. The electro-spraying nozzle needle is prepared through enabling a high-melting-point metal wire with determined outside diameter to penetrate through a quartz capillary and then carrying out nozzle needle drawing at high temperatures. The method comprises the steps of injecting lubricating fluid in the capillary by using a fluid pump firstly before the metal wire penetrates into the capillary, stretching the quartz capillary towards two sides during hot fusing, then, removing a heat source, cutting off the center of a heated part of the quartz capillary with a capillary cutter, and withdrawing the metal wire, thereby obtaining the electro-spraying nozzle needle with a determined aperture. According to the method disclosed by the invention, the operation is simple, convenient, efficient and stable, and the prepared nozzle needle is controllable in aperture and smooth in internal wall.
Description
technical field [0001] The invention discloses a method for preparing an electrospray needle with a caliber that can be stably adjusted, and belongs to the fields of analytical chemistry and proteomics. Background technique [0002] For complex biological samples with various compositions, wide dynamic range, and various structural forms, high performance liquid chromatography-mass spectrometry is a powerful means for their separation and analysis. Among them, peptides, polysaccharides, proteins and other targets carry a large number of disease-related biomarkers, and their qualitative and quantitative analysis plays an indispensable role in the diagnosis and treatment of diseases. [0003] At present, the most widely used ionization technology for liquid chromatography-mass spectrometry is the electrospray ion source. The electrospray needle used is not only a bridge between liquid chromatography and mass spectrometry, but also an important factor determining the ionization...
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IPC IPC(8): H01J49/16H01J49/04
CPCH01J49/0404H01J49/167
Inventor 张权青孙浩帆黄元宇贾善余杨灏
Owner SINOMS BIOTECH CO LTD