Induced charge electrosmosis and dielectrophoresis based microscale particle separation chip as well as preparation method and application thereof

A particle separation and dielectrophoresis technology, applied in chemical instruments and methods, fluid controllers, laboratory containers, etc., can solve the problems of complex fluid manipulation, non-compact external equipment, etc., to improve the aggregation efficiency, simplify the structure, Easy to integrate effects

Active Publication Date: 2017-06-13
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problems that the particle aggregation process in the existing continuous particle separation method based on dielectrophoresis requires complex fluid manipulation and non-compact external equipment, and cannot be directly integrated with other microfluidic chips. The osmotic effect replaces the fluid extrusion effect to complete the particle aggregation process, and proposes a micro-scale particle separation chip based on induced charge electroosmosis and dielectrophoresis, its preparation method and application

Method used

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  • Induced charge electrosmosis and dielectrophoresis based microscale particle separation chip as well as preparation method and application thereof
  • Induced charge electrosmosis and dielectrophoresis based microscale particle separation chip as well as preparation method and application thereof
  • Induced charge electrosmosis and dielectrophoresis based microscale particle separation chip as well as preparation method and application thereof

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specific Embodiment approach 1

[0046] Specific implementation mode one: combine figure 1 and figure 2 Describe this embodiment in detail. In this embodiment, a micro-scale particle separation chip based on induced charge electroosmosis and dielectrophoresis is composed of a PDMS cover sheet 9 and an ITO glass substrate 13; the PDMS cover sheet 9 is bonded to the ITO glass substrate 13 On the PDMS cover sheet 9, a channel is printed; the left end of the channel is provided with an inlet 15, the right end of the channel is provided with a third outlet 10, and the first outlet 2 is symmetrically arranged in the vertical direction in the middle of the channel. And the second outlet 12, the fourth outlet 11 is arranged under the side of the third outlet 10, and the outlet direction of the third outlet 10 is set at an angle of 6° with the outlet direction of the fourth outlet 11; The middle position of the passage is divided into three areas, the left side is the accumulation area 17, the right side is the sepa...

specific Embodiment approach 2

[0050] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the outlet width of the first outlet 2 is 350 microns, the outlet width of the second outlet 12 is 350 microns, and the width of the narrow entrance 20 is 200 microns. Microns. Others are the same as the first embodiment.

specific Embodiment approach 3

[0051] Specific Embodiment 3: This embodiment differs from Specific Embodiment 1 or 2 in that: the third excitation electrode 3 , the fourth excitation electrode 4 , the fifth excitation electrode 5 , the sixth excitation electrode 6 , and the seventh excitation electrode 7 The distance from the inner ends of two adjacent electrodes in the eighth excitation electrode 8 is equal. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses an induced charge electrosmosis and dielectrophoresis based microscale particle separation chip as well as a preparation method and application thereof and aims at solving the problem that the particle aggregation process needs complex fluid control and incompact external equipment, and particles cannot be directly integrated with other micro-fluidic chips in the traditional dielectrophoresis-based continuous particle separation method. As for the chip, the induced charge electrosmosis and dielectrophoresis based microscale particle separation chip is formed by a PDMS cover plate and an ITO glass substrate; the PDMS cover plate is bonded onto the ITO glass substrate; and a passage is printed on the PDMS cover plate. The preparation method comprises the following steps: I, processing an electrode; II, processing a passage model; III processing the PDMS cover plate; and IV, preparing the chip. The induced charge electrosmosis and dielectrophoresis based microscale particle separation chip is used for microscale particle separation.

Description

technical field [0001] The invention relates to a microscale particle separation chip based on induced charge electroosmosis and dielectrophoresis, a preparation method and application thereof. Background technique [0002] The separation of micro-scale particles is a key step in solving important problems such as water quality monitoring, early diagnosis of cancer, and environmental monitoring. To this end, separation methods such as electroosmosis, electrophoresis, dielectrophoresis, inertial force, and centrifugation have been proposed. Among these separation methods, dielectrophoresis is a separation method with relatively simple operation and strong controllability, because the operation process of particle separation based on dielectrophoresis has no moving mechanical parts, uses electric field manipulation, and operates without biological markers. Microfluidic chips based on dielectrophoretic continuous particle separation have successfully provided important support...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707B01L3/502761B01L2400/0421
Inventor 任玉坤姜洪源陈晓明陶冶侯立凯邓小康刘维宇
Owner HARBIN INST OF TECH
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