A natural gas wet desulphurization and regeneration integrated apparatus comprises a regeneration separating reactor and a filter circulating skid, and is designed in a two layer manner, the regeneration separating reactor is at the upper layer, the filter circulating skid is at the lower layer, and the regeneration separating reactor and the filter circulating skid are separated by a skidding rack; the regeneration separating reactor comprises an injection chamber A, a separation chamber B, a sulfur foam chamber C and a lean solution chamber D which are arranged from left to right, the injection chamber A is communicated with the separation chamber B, and the separation chamber B is communicated with the sulfur foam chamber C through an overflow plate, and is communicated with the lean solution chamber D through a flashboard; an injection device is arranged at the central portion of the injection chamber A from top to bottom, and the upper top of the separation chamber B is horizontally provided with a sludge scraper; and the filter circulating skid comprises a blower connected with the separation chamber B through a gas distribution tube, a rotary drum filter connected with the bottom of sulfur foam through a sulfur foam outlet tube, a separator connected with a liquid outlet of the rotary drum filter, a vacuum pump connected with the separator, and a lean solution pump connected with the bottom of the lean solution chamber D.