Novel potassium sodium dehydroandrographolide succinate compound and pharmaceutical composition thereof
A technology of Yanhuning and its compounds, which is applied in the field of new Yanhuning compounds and their pharmaceutical compositions, can solve the problems of general medicinal effect of powder injections, increased adverse reactions, and affecting the quality of preparations, so as to achieve superior drug efficacy, Excellent medicinal effect and immunity-enhancing effect
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[0047] Example 1 Preparation of new Yanhuning compound
[0048] (1) Dissolve 5g of andrographis in a mixed solution of 17.5ml of water and 2.5ml of absolute ethanol to obtain solution 1;
[0049] (2) Add 0.5 mol / L sodium bicarbonate aqueous solution to solution 1 at a rate of 20 mL / min at 20°C, adjust the pH to 6.5, then heat up to 25°C at a rate of 0.2°C / min, add activated carbon, and continue The reaction was stirred for 1 hour, filtered with suction, and the filtrate was collected to obtain solution 2;
[0050] (3) Decrease the temperature of solution 2 to 3°C at a rate of 0.2°C / min, stop stirring, let stand for 5 hours to grow crystals, filter with suction, wash the filter cake with absolute ethanol, and dry at 70°C for 4 hours to obtain Yanhuning compound.
[0051] The characteristic peaks in the X-ray powder diffraction pattern of the Yanhuning compound measured using Cu-Kα rays are 7.3°, 9.6°, 12.0°, 13.4°, 15.9°, 17.5°, 18.0°, 19.8°, 2θ. 23.4°, 23.8°, 24.6°, 27.1° display, t...
Example Embodiment
[0052] Example 2 Preparation of New Yanhuning Compound
[0053] (1) Dissolve 5g of andrographis in a mixed solution of 17.5ml of water and 2.5ml of absolute ethanol to obtain solution 1;
[0054] (2) Add 0.5mol / L sodium bicarbonate aqueous solution to solution 1 at a rate of 30mL / min at 20°C, adjust the pH to 7.0, then heat up to 30°C at a rate of 0.3°C / min, add activated carbon, continue The reaction was stirred for 2 hours, filtered with suction, and the filtrate was collected to obtain solution 2;
[0055] (3) Decrease the temperature of solution 2 to 5°C at a rate of 0.3°C / min, stop stirring, let stand for 6 hours to grow crystals, filter with suction, wash the filter cake with absolute ethanol, and dry at 80°C for 4 hours to obtain Yanhuning compound.
[0056] The X-ray powder diffraction pattern of the Yanhuning compound measured using Cu-Kα rays is consistent with that of Example 1, and the melting point is 202°C.
Example Embodiment
[0057] Example 3 Preparation of new Yanhuning compound
[0058] (1) Dissolve 5g of andrographis in a mixed solution of 17.5ml of water and 2.5ml of absolute ethanol to obtain solution 1;
[0059] (2) Add 0.5 mol / L sodium bicarbonate aqueous solution to solution 1 at a rate of 20 mL / min at 20°C, adjust the pH to 7.0, then heat up to 25°C at a rate of 0.3°C / min, add activated carbon, continue The reaction was stirred for 2 hours, filtered with suction, and the filtrate was collected to obtain solution 2;
[0060] (3) Decrease the temperature of solution 2 to 5°C at a rate of 0.2°C / min, stop stirring, let stand for 5 hours to grow crystals, filter with suction, wash the filter cake with absolute ethanol, and dry at 80°C for 4 hours to obtain Yanhuning compound.
[0061] The X-ray powder diffraction pattern of the Yanhuning compound measured using Cu-Kα rays is consistent with that of Example 1, and the melting point is 202°C.
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