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d-limonene anti-cancer synergistic composition and its preparation method and application

A technology of limonene and composition, applied in the field of d-limonene anticancer synergistic composition and preparation thereof, can solve the problems of poor stability, low efficacy, easy oxidative decomposition and the like, and achieve a remarkable effect of anticancer synergistic effect

Active Publication Date: 2020-02-11
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, there are serious side effects in the treatment of cancer (especially oral cancer) at home and abroad. In addition, the use of d-limonene to prevent and treat cancer cells generally has the problems of easy oxidation and decomposition, low efficacy and poor stability.

Method used

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  • d-limonene anti-cancer synergistic composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: 0.5% content of d-limonene anti-cancer synergistic composition and preparation method

[0031] A formula (percentage by weight) of d-limonene anticancer synergistic composition is as follows:

[0032] Anticancer active substance: 0.5%,

[0033] Synergist 1: 0.2‰,

[0034] Synergist 2: 0.5%,

[0035] Deionized Water: 99.98%.

[0036] Wherein, the anticancer active substance is d-limonene (commercially available) with a content of 98%, and the synergist 1 is a water-soluble powder of chitosan oligosaccharide with a molecular weight of 800 (produced by Shanghai Fengyu Biotechnology Development Co., Ltd.). The aforementioned synergist 2 is a non-ionic NSF-5 series plant polyenol polyoxyethylene ether (manufactured by Changshu Naisu Biomaterials Technology Co., Ltd.).

[0037] According to the formula and ratio of the anti-cancer synergistic composition mentioned above, weigh them, and then put them into the high-pressure homogenizer (manufactured by Nuoze Flu...

Embodiment 2

[0042] Example 2: d-limonene anti-cancer synergistic composition with 1% content and its preparation method

[0043] A formula (percentage by weight) of d-limonene anticancer synergistic composition is as follows:

[0044] Anticancer active substance: 1%,

[0045] Synergist 1: 0.5‰,

[0046] Synergist 2: 1%,

[0047] Distilled water: 97.95%.

[0048] Wherein, the anticancer active substance is d-limonene (commercially available) with a content of 98%, and the synergist 1 is a water-soluble powder of chitosan oligosaccharide with a molecular weight of 1500 (produced by Shanghai Fengyu Biotechnology Development Co., Ltd.). The aforementioned synergist 2 is a non-ionic NSF-5 series plant polyenol polyoxyethylene ether (manufactured by Changshu Naisu Biomaterials Technology Co., Ltd.).

[0049] According to the formula and ratio of the above-mentioned anticancer synergistic composition, weigh it, first mix it with plant polyenol polyoxyethylene ether and d-limonene, stir it pr...

Embodiment 3

[0050] Example 3: 10% content of d-limonene anti-cancer synergistic composition and its preparation method

[0051] A kind of d-limonene anti-cancer synergistic composition formula (weight percentage)

[0052] Anticancer active substances: 10%,

[0053] Synergist 1: 5‰,

[0054] Synergist 2: 10%,

[0055] Deionized water: 97.95%.

[0056] Wherein, the anticancer active substance is d-limonene (commercially available) with a content of 98%, and the synergist 1 is a water-soluble powder of chitosan oligosaccharide with a molecular weight of 1500 (produced by Shanghai Fengyu Biotechnology Development Co., Ltd.). The aforementioned synergist 2 is a non-ionic NSF-5 series plant polyenol polyoxyethylene ether (manufactured by Changshu Naisu Biomaterials Technology Co., Ltd.).

[0057] According to the formula and ratio of the above-mentioned anticancer synergistic composition, weigh it, then mix it with plant polyenol polyoxyethylene ether and d-limonene, stir and miscible prope...

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Abstract

The invention discloses a d-limonene anticancer synergistic composition and a preparation method thereof. The composition is mainly used for inhabiting cancer cell proliferation and promote cancer cell apoptosis. The d-limonene anticancer synergistic composition comprises a plant source surfactant and chitosan oligosaccharide, wherein the d-limonene anticancer synergistic composition comprises 0.5%-10% of d-limonene, 0.1%-5% of chitosan oligosaccharide and 0.5%-10% of plant source surfactant. The experiment result shows that the plant source surfactant and the chitosan oligosaccharide have a synergetic effect on the d-limonene, and the composition particularly has remarkable effects on the oral cancer cell inhibition and apoptosis.

Description

technical field [0001] The invention belongs to the field of medicine preparation for naturally inhibiting the proliferation of cancer cells, and in particular relates to a d-limonene anti-cancer synergistic composition and its preparation method and application. Background technique [0002] According to the statistics of the World Health Organization (WHO), there are 10 million new cancer patients and 6 million people die of cancer every year in the world. [0003] At present, the main measures for treating cancer at home and abroad include surgery, chemotherapy, radiotherapy and immunotherapy, but most of them have different degrees of toxic side effects or unsatisfactory curative effects. While treating cancer cells, they also bring harm to normal tissues, organs and the whole body damage, and even cause some unacceptable side effects to patients, such as the treatment of oral cancer, the postoperative damage to human facial tissue is serious, and the same is true for ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K47/36A61K47/10A61K31/015A61P35/00
CPCA61K9/1075A61K31/015A61K47/10A61K47/36
Inventor 王渊王桂琴王毅张帆蔡红艳王雪平冯帅张永光
Owner SHANXI MEDICAL UNIV