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A preparation method of microneedles with soluble needle body and insoluble substrate

A micro-needle and needle-body technology, applied in the field of micro-needles, can solve the problems of low administration efficiency of soluble micro-needles, easy drug inactivation and production time, etc., and achieve the effect of reducing time and ensuring activity.

Active Publication Date: 2019-11-29
PUTIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the above-mentioned problems of low administration efficiency of soluble microneedles, easy inactivation of drugs and long production time, the inventors provided a method for preparing microneedles in which the needle body is soluble but the substrate is insoluble;

Method used

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  • A preparation method of microneedles with soluble needle body and insoluble substrate
  • A preparation method of microneedles with soluble needle body and insoluble substrate
  • A preparation method of microneedles with soluble needle body and insoluble substrate

Examples

Experimental program
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Effect test

Embodiment 1

[0023] S1. Weigh the water-soluble polymer at room temperature, add it into distilled water, stir and dissolve, and prepare a polymer aqueous solution with a concentration of 5% by mass, and set it aside; the water-soluble polymer mentioned is polyvinyl alcohol and polyvinylpyrrolidone , polymaleic anhydride, polyacrylic acid, hydroxypropylmethylcellulose, carboxymethylcellulose, dextran and gelatin, any one or combination thereof.

[0024] S2. Adding the drug into the polymer aqueous solution to prepare a drug-containing polymer aqueous solution with a concentration of 0.1% by mass of the drug;

[0025] S3, adding a predetermined volume of the drug-containing polymer aqueous solution into the microneedle mold, using a centrifugal or vacuum method to make the drug-containing polymer solution enter the micropores of the microneedle mold, absorb the solution remaining on the surface of the microneedle mold, The microneedle mold is dried until the drug-containing polymer aqueous ...

Embodiment 2

[0028] S1. Weigh the water-soluble polymer at room temperature, add it to distilled water, stir and dissolve, and prepare a polymer aqueous solution with a concentration of 20% by mass, and set it aside; the water-soluble polymer mentioned is polyvinyl alcohol and polyvinylpyrrolidone , polymaleic anhydride, polyacrylic acid, hydroxypropylmethylcellulose, carboxymethylcellulose, dextran and gelatin, any one or combination thereof.

[0029] S2. Adding the drug into the polymer aqueous solution to prepare a drug-containing polymer aqueous solution with a concentration of 30% by mass of the drug;

[0030] S3, adding a predetermined volume of the drug-containing polymer aqueous solution into the microneedle mold, using a centrifugal or vacuum method to make the drug-containing polymer solution enter the micropores of the microneedle mold, absorb the solution remaining on the surface of the microneedle mold, The microneedle mold is dried until the drug-containing polymer aqueous so...

Embodiment 3

[0034] S1. Weigh the water-soluble polymer at room temperature, add it to distilled water, stir and dissolve, and prepare a polymer aqueous solution with a concentration of 15% by mass, and set it aside; the water-soluble polymer mentioned is polyvinyl alcohol and polyvinylpyrrolidone , polymaleic anhydride, polyacrylic acid, hydroxypropylmethylcellulose, carboxymethylcellulose, dextran and gelatin, any one or combination thereof.

[0035] S2, adding the drug into the polymer aqueous solution to prepare a drug-containing polymer aqueous solution with a concentration of 20% by mass of the drug;

[0036]S3, adding a predetermined volume of the drug-containing polymer aqueous solution into the microneedle mold, using a centrifugal or vacuum method to make the drug-containing polymer solution enter the micropores of the microneedle mold, absorb the solution remaining on the surface of the microneedle mold, Dry the microneedle mold until the drug-containing polymer aqueous solution...

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Abstract

The invention relates to a preparation method of a microneedle with a soluble needle body and an insoluble substrate. The preparation method comprises the following steps: weighing water soluble macromolecules at room temperature, adding the water soluble macromolecules into distilled water, stirring, dissolving, and preparing a macromolecule aqueous solution for standby use; adding drugs into the macromolecule aqueous solution to prepare a drug-containing macromolecule aqueous solution; adding a preset volume of the drug-containing macromolecule aqueous solution into a microneedle mold, enabling the drug-containing macromolecule aqueous solution to enter micropores of the microneedle mold by utilizing a centrifugal method, sucking the solution remaining on the surface of the microneedle mold, and drying the microneedle mold until the drug-containing macromolecule aqueous solution forms a needle body layer of the microneedle in the microneedle mold; and heating a material with a preset low melt point until the material is molten, adding into the microneedle mold containing the microneedle needle body layer, placing a steel plate above the molten material, pressing the steel plate downwards for multiple times until the molten material is pressed into the micropores of the microneedle mold, standing, enabling a substrate layer to be solidified, and stripping to obtain the microneedle with the soluble needle body and the insoluble substrate. The dosing efficiency of the soluble microneedle is increased.

Description

technical field [0001] The invention relates to the field of microneedle technology, in particular to a method for preparing a microneedle with a soluble needle body and an insoluble substrate. Background technique [0002] Microneedle is an array of needle-like protrusions in the micron range, mainly used for transdermal delivery of drugs; it is as effective as hypodermic needles and as convenient as traditional transdermal patches, and has become a research hotspot in the field of formulations one. As one of the most popular types, soluble microneedles have the advantages of being suitable for mass production, easy to use, high biocompatibility, and not producing sharp medical waste. The current manufacturing methods of dissolvable microneedles mainly include mold casting (accounting for the majority) and "stepwise controlled drawing". The mold casting method is generally divided into two steps: first inject the solution containing the drug into the mold, and form a need...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 陈健敏黄子尧黄玮玥
Owner PUTIAN UNIV