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Bilobalide drop pill and preparation method thereof

A technology of ginkgolide and dripping pills, applied in the field of medicine, can solve the problems of aging of ginkgolide dripping pills and the like

Active Publication Date: 2017-07-07
CHENGDU BAIYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of ginkgolide dropping pill and preparation method thereof, to solve the aging problem of ginkgolide dropping pill in the prior art

Method used

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  • Bilobalide drop pill and preparation method thereof
  • Bilobalide drop pill and preparation method thereof
  • Bilobalide drop pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 ginkgolide dropping pills of the present invention

[0029] prescription:

[0030]

[0031] Preparation process: take 1 kg of ginkgolide, crush the ginkgolide through a 100-mesh sieve to obtain fine ginkgolide powder, and set aside; take 3.0 kg of PEG4000, add 0.2 kg of polysorbate-80, and then add 0.2 kg of CMC-Na, heat to melt, add ginkgolide fine powder at 80°C, stir to suspend, then drop the medicinal material into liquid paraffin at 10°C through the dropper to cool, shape, and obtain 100,000 Pills, 44mg per pill.

Embodiment 2

[0032] The preparation of embodiment 2 ginkgolide dropping pills of the present invention

[0033] prescription:

[0034]

[0035] Preparation process: take 1kg of ginkgolide, crush the ginkgolide through a 150-mesh sieve to obtain fine ginkgolide powder, and set aside; take 4kg of PEG6000, add 0.6kg of CMC-Na, heat to melt, and keep warm at 100°C Add ginkgolide fine powder under the state, stir to make it suspend, then drop the medicine material into the vegetable oil of 15 ℃ through the dropper to cool, shape, get 100,000 drop pills, each pill 56mg.

Embodiment 3

[0036] The preparation of embodiment 3 ginkgolide dropping pills of the present invention

[0037] prescription:

[0038]

[0039] Preparation process: take 1 kg of ginkgolide, crush the ginkgolide through a 200-mesh sieve to obtain a fine powder of ginkgolide, and set aside; take a mixture of 1.5 kg of PEG4000 and 1.5 kg of PEG6000, and add 0.2 kg of calcined Add 0.5kg of CMC-Na, heat to melt, add ginkgolide fine powder at 95°C, stir to suspend, and then drop the drug material into the liquid paraffin at 15°C through the dropper Cool in middle, molding, get 100,000 drop pills, every pill 46mg.

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PUM

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Abstract

The invention discloses a bilobalide drop pill. The bilobalide drop pill is prepared from, by weight, 10 parts of bilobalide, 20-40 parts of matrix and 2-6 parts of disintegrating agent. The invention further provides a preparation method of the bilobalide drop pill. Acceleration experiment results show that with the disintegrating agent CMC-Na added into a preparation formula, the bilobalide drop pill is free of obvious change on dissolution rate in vitro and dissolution time limit after 6 months, thereby being high in stability and capable of avoiding ageing effectively.

Description

technical field [0001] The invention relates to a ginkgolide dripping pill and a preparation method thereof, relating to the field of medicine. Background technique [0002] Ginkgolides belong to terpenoids, mainly including ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide M, ginkgolide J and bilobalide, etc., and its chemical structure is shown in the following formula. [0003] [0004] Scientific research shows that ginkgolide is a natural platelet activating factor (PAF) receptor antagonist, which can dilate coronary vessels, improve cerebral circulation, inhibit platelet aggregation, prevent atherosclerosis, antagonize increased vascular permeability, and relieve bronchoconstriction Pharmacological effects such as heart and brain ischemic injury, the central nervous system has a protective effect, anti-aging, anti-shock, anti-allergic, anti-bacterial, anti-inflammatory, anti-tumor, anti-rejection in organ transplantation, and also has effects on liver and kidney ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/365A61K47/38A61P9/10A61P7/02A61P11/00A61P25/00A61P39/06A61P37/08A61P31/04A61P29/00A61P35/00A61P37/06A61P1/16A61P13/12
CPCA61K9/2054A61K31/365
Inventor 杨勇陈彦
Owner CHENGDU BAIYU PHARMA CO LTD
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