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A technology for intestinal mucosal injury and soft capsules, applied in capsule delivery, anti-drugs, digestive system, etc., can solve the problems of difference in effect, limited therapeutic effect, etc., achieve reduced expression, maintain relatively stable, and improve the effect of injury
Inactive Publication Date: 2017-07-14
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
[0004] The current drugs for the treatment of intestinal mucosal injury caused by chemotherapy have very limited therapeutic effects, and the effects vary
Method used
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Embodiment 1
[0023] Example 1 Preparation of Amomum villosum volatile oil
[0024] Choose Amomun villosum Lour introduced from Yunnan, pulverize and accurately weigh 100g into a round bottom flask, add 600ml of distilled water, soak for half an hour, extract by steam distillation for 8h, collect the volatile oil, and dry it with anhydrous sodium sulfate Store in the refrigerator at -4°C.
Embodiment 2
[0025] Example 2 Protective effect of Amomum villosum volatile oil on intestinal mucosal injury in rats induced by 5-FU
[0026] (1) Preparation and administration method of intestinal mucosal injury model
[0027] 48 SD rats were used in the experiment, divided into normal group (CON), model group (MOD), positive drug gold bifidus group (CBL, 450mg / kg), Amomum villosum low dose group (VOA.L, 8mg / kg), sand The middle-dose group of volatile oil of Amomum villosum (VOA.M, 16mg / kg), the high-dose group of volatile oil of Amomum villosum (VOA.H, 32mg / kg). Except for the normal group, the rats in the other groups received chemotherapy for a total of 5 days, and 5-fluorouracil (5-FU) was injected intraperitoneally at a dose of 35 mg / kg every day. 4 hours before chemotherapy, each group was given the therapeutic drugs by gavage on an empty stomach, and the normal group and model group were gavage with equal volume of saline for a total of 12 days. During the experiment, the weight and f...
Embodiment 3
[0045] Example 3 Preparation of soft capsules
[0046] Take the volatile oil of Amomum villosum, add 1.5 times the amount of soybean oil base, stir to make it evenly dispersed, pass through colloid mill, and press into soft capsules, which is ready. The soft capsule shell uses gelatin: glycerin: water in a ratio of 1:0.5:1 Prepared.
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Abstract
The invention relates to a Fructus Amomi volatile oil soft capsule for alleviating chemotherapy induced intestinal mucosa damage, provides a use of Fructus Amomi volatile oil in the preparation of drugs for alleviating chemotherapy induced intestinal mucosa damage, and also provides a soft capsule for alleviating chemotherapy induced intestinal mucosa damage, and a preparation method thereof. The soft capsule comprises an effective component Fructus Amomi volatile oil, a matrix, and a soft capsule shell produced from gelatin, glycerin and water according to a ratio of (1-1.5):(0.2-0.8):(1-1.5). The Fructus Amomi volatile oil improves the body weight reduction, the appetite decrease and the diarrhea induced by a chemotherapy drug 5-FU, inhibits the rising of 5-FU induced inflammation factors, reduces the expression of cell apoptosis proteases, inhibits LPS from entering blood, and increases the expression of intestinal tight junction proteins in order to improve the F-5FU induced rat intestinal mucosa barrier damage. The Fructus Amomi volatile oil increase the intestinal probiotics, reduces the relative abundance of conditioned pathogens, improves the imbalance of 5-FU induced intestinal florae, and keeps the relative stability of the intestinal micro-ecology.
Description
Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a soft capsule of Amomum villosum volatile oil for relieving intestinal mucosal damage caused by chemotherapy. Background technique [0002] Chemotherapy plays an important role in the treatment of malignant tumors. However, while chemotherapeutic drugs kill tumor cells, they also have toxic effects on normal cells. Investigations have shown that the intestinal barrier function of cancer patients is severely damaged after repeated chemotherapy. On the one hand, the effective absorption area of the intestinal mucosa is reduced, causing nutrient absorption disorders and varying degrees of bleeding, diarrhea, pain, etc.; on the other hand, intestinal permeability Increase, the displacement of the intestinal flora, the patient's immunity is reduced, and the infection rate and mortality rate are increased. Therefore, improving the intestinal mucosal damage and related gastroin...
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