Parameter for reflecting biological tissue abnormity and measuring method thereof
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A technology for measuring biological tissue and parameters, applied in the field of hypothesis testing, it can solve problems such as a large number of samples and complex calculations, and achieve the effects of high versatility, simple calculation, and accurate measurement.
Inactive Publication Date: 2017-07-28
NANJING UNIV
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[0007] However, the above application has the problem of using artificial neural network or intelligent organization classifier as mentioned above, which requires a large number of samples and complex calculations, which still needs further improvement
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Embodiment 1
[0043] see figure 1 , a method for measuring parameters reflecting abnormalities in biological tissues of the present embodiment, the specific steps are as follows:
[0044]1) Set the Vinno70 B-ultrasound diagnostic instrument (VINNO Technology (Suzhou) Co., Ltd.) in the second harmonic scanning mode, use the X6-16L broadband B-ultrasound probe to scan the tissue, and obtain the original RF (ultrasonic RF) data.
[0045] The second harmonic p generated when ultrasound propagates in inhomogeneous tissue 2 The relationship between (x) and the nonlinear parameter B / A of the tissue can be expressed as
[0046]
[0047] in is the nonlinear parameter at position x, α 1 (v), α 2 (v) are the attenuation coefficients of the fundamental frequency and the second harmonic, respectively, p 0 , f are fundamental sound pressure and frequency, respectively, ρ, c are tissue density and sound velocity. The nonlinear parameter is the quantity that expresses the nonlinear effect in t...
Embodiment 2
[0066] A parameter reflecting the abnormality of biological tissue and its measurement method in this embodiment are basically the same as in Embodiment 1, the difference is that in step 2) of this embodiment, in order to ensure the extraction of the second harmonic signal and avoid noise interference, The bandwidth is set to 40% of the center frequency. In step 4), N is set to 1, that is, the root mean square value of every 5 scanning points is calculated.
Embodiment 3
[0068] A parameter reflecting the abnormality of biological tissue and its measurement method in this embodiment are basically the same as in Embodiment 1, the difference is that in step 2) of this embodiment, in order to ensure the extraction of the second harmonic signal and avoid noise interference, The bandwidth is set to 60% of the center frequency. In step 4), N is set to 3, that is, the root mean square value of every 15 scanning points is calculated.
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Abstract
The invention discloses a parameter for reflecting biological tissue abnormity and a measuring method thereof, and belongs to the technical field of hypothesis testing in B-mode ultrasound diagnosis and statistics. The method comprises the steps of firstly setting a B-mode ultrasound diagnosis apparatus into a second harmonic scanning mode to scan and store original RF data of tissue; secondly conducting band-pass filtering on one frame of the RF data to select interested and reference areas in the frame of the RF data; then calculating the root-mean-square value of second harmonics in each cycle or several cycles on each scanning line in the interested area and reference area; then conducting Kolmogorov-Smirnov testing to conduct comparison on the root-mean-square value and the reference value of the each scanning line in each area, and calculating a corresponding p value; finally using the arithmetic mean p value of the interest area to divide the arithmetic mean p value of the reference value to obtain the corresponding p value. According to the parameter for reflecting biological tissue abnormity and the measuring method thereof, the problems that subjectivity is strong in identification of complex biological tissue abnormity in current B-mode ultrasound diagnosis and rich clinical experiences are needed in the current B-mode ultrasound diagnosis are solved, and measurement is accurate, and implementation is conducted easily.
Description
technical field [0001] The present invention relates to B-ultrasound examination and hypothesis test in statistics, especially the technique of reflecting the abnormality of biological tissue characteristics; more specifically, it relates to a parameter reflecting the abnormality of biological tissue and its measuring method. Background technique [0002] Ultrasound examination is a method for detecting tissue abnormalities by displaying and recording the ultrasonic waves reflected by organs in the form of waveforms or images according to the differences in the acoustic properties of human organs and tissues. Currently the most widely used is B-ultrasound. It has the advantages of high resolution, simple operation, fast imaging, timely diagnosis, no pain and no harm to the soft tissue of the human body, and it is a non-invasive examination. The wide application of ultrasound imaging technology has promoted the research process of using computer technology and information pr...
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