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Aeromonas salmonicida phage, bactericidal composition comprising same and application of bactericidal composition

A technology of Aeromonas salmonicida and phage, applied in the field of Aeromonas salmonicida phage and bactericidal composition, which can solve the problems of evolutionary phage, high dose, narrow host spectrum range, etc.

Active Publication Date: 2017-08-29
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as far as the current application of single phage therapy is concerned, some potential disadvantages gradually appear in the application process, such as a narrow range of host spectrum that can be lysed, a high dose required to lyse a certain number of hosts, and hosts evolving phage resistance in a short period of time. sex etc.

Method used

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  • Aeromonas salmonicida phage, bactericidal composition comprising same and application of bactericidal composition
  • Aeromonas salmonicida phage, bactericidal composition comprising same and application of bactericidal composition
  • Aeromonas salmonicida phage, bactericidal composition comprising same and application of bactericidal composition

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Embodiment

[0075] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

[0076] The invention discloses a phage cocktail preparation for efficiently cracking Aeromonas salmonicida atlantis. Using a strain of broad-spectrum drug-resistant pathogenic Aeromonas salmonicida isolated from the muscle, liver, and kidney of Atlantic salmon with skin ulceration as the host, 10 cleavage phage strains were isolated from the water enviro...

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Abstract

The invention relates to an aeromonas salmonicida phage, a bactericidal composition comprising the same and an application of the bactericidal composition. The phage is capable of quickly inhibiting growth of Atlantic aeromonas salmonicida within a short period of time and inhibiting generation of resistance of the pathogenic bacterium phage. In addition, the bactericidal composition comprising the phage is safe and effective, and is high in specificity and low in production cost, and the disadvantages of single phagotherapy are compensated in the control process of pathogenic bacterium.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to Aeromonas salmonicida bacteriophage, a bactericidal composition containing it and applications thereof. Background technique [0002] Aeromonas salmonicida (Aeromonas salmonicida) belongs to the gram-negative bacilli of the genus Aeromonas under the Proteobacteria. The main pathogenic bacteria of furunculosis and ulcer disease. Aeromonas salmonicida has a broad host range and, in some cases, is responsible for a variety of infectious diseases in humans and animals, both in and out of the intestinal tract. Under high-density farming conditions, due to the high lethality and morbidity rate of Aeromonas salmonicida, this type of pathogenic bacteria is considered to be one of the main causes of explosive deaths of various aquatic animals. Trout losses were severe. In addition, this type of pathogenic bacteria can infect non-salmonidae fish, which has brought huge economic losses to aq...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N7/00A61K35/76A61P31/04C12R1/92
CPCA61K35/76C12N7/00C12N2795/00021C12N2795/00032Y02A50/30
Inventor 马迎飞陈玲袁盛建
Owner SHENZHEN INST OF ADVANCED TECH
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