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Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin

A composition, the technology of pterostilbene, applied in the directions of skin care preparations, drug combinations, skin diseases, etc., can solve the problems of poor bioavailability of resveratrol, hindering the effect of chemical protective agents, short half-life and the like

Inactive Publication Date: 2017-08-29
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, resveratrol seems unlikely to be useful as a chemoprotectant in humans (at least not as a single agent) due to its poor bioavailability (Roupe, K.A., et al. "Pharmacometrics of stilbenes: seguing towards the clinic, "Curr. Clin. Pharmacol. (2006) 1: 81-101)
Resveratrol is well tolerated in humans, but is easily metabolized (via UGT) resulting in a short half-life, which hampers its effectiveness as a chemoprotectant (Cottart C.H., et al., "Resveratrol bioavailability and toxicity in humans , "Mol.Nutr.Food Res.(2010)54:7-16)

Method used

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  • Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin
  • Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin
  • Topical pterostilbene compositions for use in treating UV-induced loss of barrier function in skin

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Pterostilbene Treatment Prevents Noxious UV-B-Mediated Skin Damage Including Transepidermal Water Loss (TEWL) in SKH-1 Mice.

[0046] The efficacy of pterostilbene in preventing UV-mediated skin damage was assessed using hairless SKH-1 mice. The SKH-1 model is well suited for this purpose and is often used in preclinical studies with valuable results. Resveratrol was previously shown to prevent abnormal skin changes in mice (Reagan-Shaw, S., et al., 2004). We repeated these experiments to determine whether pterostilbene also prevented these molecular changes. Specifically, 15 adult female SKH-1 (hairless) mice were subjected to a 30-min UV-B radiation (180mJ / cm 2 ). All topical treatments were applied to the dorsal skin of mice in a total volume of 200 μl. For the acetone group, 200 μl of acetone was administered. For the resveratrol and pterostilbene group, appropriate stilbene was administered at a concentration of 10 μmol / 0.2 ml acetone / mouse. These mice were ...

Embodiment 2

[0048] In another embodiment, the efficacy of orally administered pterostilbene in preventing UV-mediated SCC in SKH-1 mice can be demonstrated.

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Abstract

A chemoprotective method for treating, inhibiting or preventing loss of barrier function in skin caused by ultraviolet (UV) light by using an effective amount of pterostilbene is provided. Pharmaceutical and nutraceutical compositions containing pterostilbene suitable for administration to an individual in order to prevent subsequent UV-mediated loss of barrier function in skin are provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 62 / 046,068, filed September 4, 2014, which is hereby incorporated by reference. [0003] A note about federally funded research [0004] This invention was made with government support under Grant No. P30CA62330 awarded by the National Cancer Institute and Grant No. R03ES019668 awarded by the National Institute of Environmental Health Sciences. The government has certain rights in this invention. technical field [0005] Chemoprotective methods for treating, inhibiting or preventing ultraviolet (UV) light-induced impairment of skin barrier function using an effective amount of pterostilbene are described. Pharmaceutical and nutritional compositions comprising pterostilbene are described which are suitable for administration to an individual to prevent subsequent UV-mediated impairment of the skin barrier function. Compositions comprising pterostilbe...

Claims

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Application Information

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IPC IPC(8): A61Q17/00
CPCA61K47/26A61K9/08A61P35/00A61P17/00A61K31/09A61K9/0014
Inventor 小F·L·梅斯肯斯R·W·德林杰
Owner RGT UNIV OF CALIFORNIA
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