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Cosmetic and cosmeceutical compositions for restoration of skin barrier function

A composition and skin care technology, applied in cosmetic preparations, cosmetic preparations, synthetic active ingredients of polymeric materials, etc., can solve problems such as change

Inactive Publication Date: 2008-03-19
GENEPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alteration of the barrier will alter the calcium ion gradient in the skin, leading to a barrier repair process

Method used

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  • Cosmetic and cosmeceutical compositions for restoration of skin barrier function
  • Cosmetic and cosmeceutical compositions for restoration of skin barrier function
  • Cosmetic and cosmeceutical compositions for restoration of skin barrier function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0213] Embodiment 1: Cosmetic aqueous solution

[0214] This example describes one embodiment of the composition of the present invention, which is an aqueous solution, useful as a skin lotion. The solution composition is as follows:

[0215] Sodium chloride 2.13%

[0216] Potassium chloride 0.48%

[0217] Potassium Bromide 0.54%

[0218] Magnesium Chloride 2.02%

[0219] Calcium chloride 2.06%

[0220] Glycerin 1.02%

[0221] Water 91.54%

[0222] Preservatives 0.21%

[0223] The solution contains calcium ions in combination with other salts in the composition to restore the homeostasis of the major ionic components of the skin. Monovalent ions potassium and sodium from NaCl, KCl, KBr and from MgCl 2 and CaCl 2 The proportion balance between the divalent ions. Careful preparation of the mixture avoids the phenomenon of "salting out," in which the addition of the more water-soluble salt forces the less water-soluble salt to crystallize. Glycerol was used to maintai...

Embodiment 2

[0225] Example 2: Skin Care Cream

[0226] This example describes one embodiment of the composition of the present invention, which is a water-oil emulsion, useful as a skin care cream. The ingredients of the emulsion (referred to as Cream Formulation I) are as follows:

[0227] Pentaerythritol tetracaprylate / tetracaprate 5.2%

[0228] Emulsifying Wax 3.9%

[0229] Behentrimonium methosulfate (and) X 3.15%

[0230] Cetearyl alcohol

[0231] Mineral oil 0.88%

[0232] Soybean Oil 1.06%

[0233] Lanolin Alcohol 0.51%

[0234] Water 81.72%

[0235] Calcium chloride 0.22%

[0236] Glycerin 1.9%

[0237] Wheat amino acids 0.53%

[0238] Preservatives 0.93%

[0239] Aromatic amount

[0240] In a variation of this embodiment, a water-oil emulsion is prepared using the ingredients described above, except that the concentration of calcium chloride is reduced and other divalent cations such as magnesium and monovalent cations such as sodium and potassium are added. The comp...

Embodiment 3

[0260] Example 3: Skin Care Gel

[0261] This example describes one embodiment of the composition of the present invention, which is a silicone based gel, useful as a skin care gel. The gel composition is as follows:

[0262] Cyclopentasiloxane (and) Dimethicone Crosslinked 70.44%

[0263] Polymer (and) Cyclohexasiloxane

[0264] Cyclomethicone 19.52%

[0265] Propylene Glycol 3.64%

[0266] Soluble Collagen 0.49%

[0267] Hydrolyzed Silk Protein 0.72%

[0268] Tocopheryl Acetate 0.45%

[0269] Glycerin 2.98%

[0270] Marine Collagen Amino Acids 0.53%

[0271] Calcium chloride 0.21%

[0272] Preservatives 1.02%

[0273] This example combines calcium ions with amino acids to enhance collagen production and anti-aging properties. The mere addition of exogenous calcium is not believed to be sufficient to promote collagen production in the skin. The soluble collagen in the gel is designed to directly supply the essential skin components, while the collagen amino acids ...

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PUM

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Abstract

Compositions, kits and methods are provided for restoring skin barrier function to skin exposed to environmental elements and / or in a pathological condition. In general, divalent cations such as calcium ions and / or magnesium ions are included in a physiologically acceptable medium. In some embodiments, divalent cations are balanced with monovalent cations such as sodium and potassium ions at appropriate ratios in order to maintain the homeostasis of skin barrier. The compositions, kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving skin condition, and preventing or treating dermatological diseases and skin disorders.

Description

[0001] cross reference [0002] This application claims priority to US Provisional Patent Application 60 / 652,196, filed February 11, 2005, the contents of which are incorporated herein by reference. Background of the invention [0003] The skin has many functions, but its first function is to act as a protective or barrier layer. The most important function of the skin of terrestrial animals is to protect the moisture-rich internal organs from a dry environment. This skin barrier function of the skin resides in the uppermost thin layer (approximately 10-20 μm in humans) called the stratum corneum. This layer is 1,000 times more water-impermeable than other membranes in living organisms. Potts & Francoeur (1991) J. Invest. Dermatol. 96:495-499. [0004] The stratum corneum is composed of two components, protein-rich nonviable cells and intercellular lipid regions. Elias et al. (1993) Curr. Opin. Dermatol. 231-237. Lipid molecules in the intercellular region form a bilayer ...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K31/74A61K8/02A61K33/14
Inventor H·塔纳乔黄新凡
Owner GENEPHARM
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