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Aeromonas salmonicida bacteriophage, sterilization composition with same and application of same

A technology of Aeromonas salmonicida and bacteriophage, which is applied in the field of Aeromonas salmonicida phage and bactericidal composition, and can solve the problems of high dosage, evolved phage, and narrow range of host spectrum

Active Publication Date: 2017-09-01
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as far as the current application of single phage therapy is concerned, some potential disadvantages gradually appear in the application process, such as a narrow range of lysable hosts, a high dose required to lyse a certain number of hosts, and the hosts evolving phage resistance within a short period of time. sex etc.

Method used

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  • Aeromonas salmonicida bacteriophage, sterilization composition with same and application of same
  • Aeromonas salmonicida bacteriophage, sterilization composition with same and application of same
  • Aeromonas salmonicida bacteriophage, sterilization composition with same and application of same

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Embodiment

[0075] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate specific conditions in the examples carry out according to conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

[0076]The invention discloses a research on a phage cocktail preparation for efficiently cracking Aeromonas salmonicida. Using a strain of broad-spectrum drug-resistant pathogenic Aeromonas salmonicida isolated from the muscle, liver, and kidney of Atlantic salmon with skin ulceration as the host, 10 cleavage phage strains were isolated from the water environment, and t...

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Abstract

The invention relates to aeromonas salmonicida bacteriophage, a sterilization composition with the same and application of the same. The bacteriophage is capable of rapidly inhibiting growth of Atlantic aeromonas salmonicida within a short time, and inhibiting generation of resistance of the pathogenic bacterium bacteriophage. In addition, the sterilization composition with the bacteriophage is safe and effective, high in specificity and low in production cost, and defects of single bacteriophage phagotherapy can be made up in the control process of pathogenic bacteria.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular, to Aeromonas salmonicida phage, a bactericidal composition containing it and applications thereof. Background technique [0002] Aeromonas salmonicida (Aeromonas salmonicida) belongs to the gram-negative bacilli of the genus Aeromonas under the Proteobacteria. The main pathogenic bacteria of furunculosis and ulcer disease. Aeromonas salmonicida has a broad host range and, in some cases, is responsible for a variety of infectious diseases in humans and animals, both in and out of the intestinal tract. Under high-density farming conditions, due to the high lethality and morbidity rate of Aeromonas salmonicida, this type of pathogenic bacteria is considered to be one of the main causes of explosive deaths of various aquatic animals. Trout losses were severe. In addition, this type of pathogenic bacteria can infect non-salmonidae fish, which has brought huge economic losses to aquacultu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N7/00A61K35/76A61P31/04A61P17/02C12R1/92
CPCA61K35/76C12N7/00C12N2795/00021C12N2795/00032A61K2300/00Y02A50/30
Inventor 马迎飞陈玲袁盛建
Owner SHENZHEN INST OF ADVANCED TECH
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