Digital micro-mirror array-based parallel confocal microscopy imaging device and method

A confocal microscopic imaging and digital micromirror array technology, which is used in measurement devices, material analysis by optical means, instruments, etc., can solve the problem that optical parameters are difficult to change, the consistency and uniformity of optical performance cannot be guaranteed, and optical parameters cannot be changed. and other problems to achieve the effect of improving stability and realizing flexible measurement

Pending Publication Date: 2017-09-01
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Problems solved by technology

Although the Nipkow disk method can greatly increase the scanning speed, its light energy utilization rate is low, and the rotation of the Nipkow disk will affect the stability and accuracy of the system.
The microlens array method is currently the most widely used method, and its light energy utilization rate has been greatly improved compared with the Nipkow disk, but the manufacturing process of the microlens itself is relatively complicated, and the consistency of the focal length of the lens is difficult to strictly control
Regardless of the Nipkow disk or the microlens array, after

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  • Digital micro-mirror array-based parallel confocal microscopy imaging device and method
  • Digital micro-mirror array-based parallel confocal microscopy imaging device and method
  • Digital micro-mirror array-based parallel confocal microscopy imaging device and method

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[0033] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0034] see image 3 , 4 , 5. The present invention discloses a parallel confocal microscopic imaging device based on a digital micromirror array. Lens 9, camera 10 and central control device 11.

[0035] The lighting unit includes a light source 1 and a lighting lens 2;

[0036] image 3 The middle light splitting unit chooses the first scheme, including a dichroic mirror 31 and an emitting sheet 32. The light transmission range of the dichroic mirror 31 m...

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Abstract

The invention discloses a digital micro-mirror array-based parallel confocal microscopy imaging device and method. A digital micro-mirror device is ingeniously utilized as a beam splitter, and serves as a lighting pinhole and a detection pinhole at the same time, so that a multi-point parallel confocal imaging mode is achieved through combination of a light source, a camera and related optical assemblies. A system can adapt to the imaging requirements of different samples to achieve flexible measurement while a high scanning rate and a high light energy utilization rate are met; and the influence of mechanical vibration is avoided and the stability of the system is improved.

Description

technical field [0001] The invention relates to the technical field of microscopic imaging, more specifically, to a parallel confocal microscopic imaging device and method based on a digital micromirror array. Background technique [0002] With the development of technology in the past ten years, confocal imaging can balance the advantages and disadvantages of traditional optical microscopy and electron microscopy. It not only has the ability to observe the surface and interior of living cells in real time, but also has a high three-dimensional It is widely used in biomedicine, materials science and other fields. [0003] Traditional confocal imaging is generally carried out by single-point scanning, the scanning speed is slow, the mechanical control for manipulating the movement of the scanning head is complex, and the vibration caused by its own rotation will lead to certain measurement errors. [0004] With the development of confocal technology, single-point confocal sc...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/84
CPCG01N21/6458G01N21/84
Inventor 朱茜杨西斌李辉
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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