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Novel application of cortex dictamni extract

A kind of technology of extract and white fresh bark, which is applied in the field of new application of white fresh bark extract

Inactive Publication Date: 2017-09-22
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

There is no relevant report showing that the water extract of Cortex alba has the effect of treating myocardial ischemia-reperfusion injury after ethanol extraction and precipitation

Method used

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  • Novel application of cortex dictamni extract
  • Novel application of cortex dictamni extract
  • Novel application of cortex dictamni extract

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Embodiment Construction

[0020] In the following two aspects, the pharmacodynamic effect of the extract of the white fresh cortex on hypoxia-reoxygenation of myocardial cells and the pharmacological effect on the myocardial ischemia-reperfusion injury of rats, the clinical effect of the extract of the white fresh cortex on the treatment of myocardial ischemia-reperfusion injury The beneficial effect of the present invention is illustrated by previous studies.

[0021] 1 Pharmacodynamic experiment of the extract of fresh cortex

[0022] 1.1 Test materials and instruments

[0023] Cortex alba (purchased from Anguo Medicinal Materials Market, identified by Professor Chang Qi), H9c2 cardiomyocyte cell line (Cell Resource Center, Institute of Basic Theory, Chinese Academy of Medical Sciences), DMEM high-glucose medium (Gibco, USA), fetal bovine serum ( American Gibco company), BSA (American Amersco company), eomycin sodium for injection (Harbin Pharmaceutical Group Pharmaceutical General Factory), strepto...

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Abstract

The invention relates to a traditional Chinese medicine extract. After traditional Chinese medicine cortex dictamni is subjected to water extraction, impurities are removed through ethanol precipitation, spray drying is carried out, and the traditional Chinese medicine extract is obtained. The traditional Chinese medicine extract has an obvious protection on hypoxia reoxygenation of myocardial cells, and can reduce the myocardial infarction area, obviously reduce the rise of the S-T section of a rat myocardial ischemia reperfusion injury electrocardiography, improve the activity of superoxide dismutase (SOD), reduce the content of malondialdehyde (MDA), reduce the activity of creatine kinase (CK), relieve the pathological lesion of myocardial ischemia reperfusion, and thus relieve the rat myocardial ischemia symptom.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a new application of an extract of white fresh bark. Background technique [0002] In recent years, the incidence of ischemic cardiomyopathy in China has been increasing. The main cause of the disease is the reduction of coronary blood flow caused by various reasons, and then the myocardial blood supply is blocked, the supply of nutrients is insufficient and the clearance of metabolites is reduced, resulting in myocardial Cell damage or even death. With the interventional surgery of heart disease, including coronary angiography, PTCA + stent, mitral valve dilatation, radiofrequency ablation, pacemaker implantation, congenital heart disease interventional treatment, coronary artery thrombolysis The establishment, popularization and application of surgery and other methods can reperfuse heart tissues and organs with blood after ischemia. In most cases, reperfusion after ische...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61P9/10
CPCA61K36/75A61K2236/331A61K2236/39A61K2236/53
Inventor 许扬
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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