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Medicine for treating chronic glomerulonephritis and nephrotic syndrome and preparation method thereof

A technology for glomerulonephritis and nephrotic syndrome, applied in the field of medicine, can solve the problems of side effects, limited effect, and different efficacy of nephrotic syndrome, and achieve the effect of reducing proteinuria

Active Publication Date: 2021-02-05
贵州中医药大学第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the treatment of chronic nephritis and nephrotic syndrome mainly focuses on the use of glucocorticoids and immunosuppressants, which are effective in controlling the disease, but the effect is limited in cases of refractory nephropathy and there are many side effects. To a certain extent, its use is limited; secondly, the reduction of proteinuria mainly depends on the use of ACEI / ARB, which requires a large dose and a full course of treatment. It has different curative effects on different types of chronic nephritis and nephrotic syndrome, and there are blood pressure, blood Creatinine and other restrictions on use

Method used

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  • Medicine for treating chronic glomerulonephritis and nephrotic syndrome and preparation method thereof
  • Medicine for treating chronic glomerulonephritis and nephrotic syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Formula: Astragalus 25kg, Dijincao 17kg, Codonopsis 15kg, Cornus 15kg, Rehmannia glutinosa 17kg, Atractylodes macrocephala 13kg, Poria cocos 13kg and Alisma 13kg.

[0045] Process: Take the above medicine, add 9 times the amount of water to soak for 13 minutes, first decoct on high heat for 13 minutes, then continue to decoct on low heat for 20 minutes, decoct 3 times, filter, combine the filtrate, and the filtrate is concentrated to 50-60 ° C. For the extract with a density of 1.20-1.25, take 30% starch and 0.7% magnesium stearate to mix with the extract, granulate with 60% ethanol, dry, crush, and fill capsules to obtain capsules agent.

[0046] Specification: 0.5g / grain;

[0047] Usage and dosage: 2-3 times a day, 2-3 capsules each time.

Embodiment 2

[0049] Formula: Astragalus 27kg, Dijincao 19kg, Codonopsis 17kg, Cornus 17kg, Rehmannia glutinosa 19kg, Atractylodes macrocephala 14kg, Poria cocos 14kg and Alisma 14kg.

[0050] Process: Take the above-mentioned medicine, add 9 times the amount of water to soak for 13 minutes, first decoct on high heat for 13 minutes until boiling, then continue to decoct on low heat for 20 minutes, filter, add 5 times the amount of water to the filter residue and decoct twice, each time After 30 minutes, filter and combine the filtrates to obtain the decoction.

[0051] Usage and dosage: 2-3 times a day, 100mL each time.

Embodiment 3

[0053] Formula: Astragalus 23kg, Dijincao 16kg, Codonopsis 13kg, Cornus 13kg, Rehmannia glutinosa 16kg, Atractylodes macrocephala 12kg, Poria cocos 12kg and Alisma 12kg.

[0054] Process: Take the above medicine, add 8-10 times the amount of water to soak for 10-15 minutes, first decoct on high heat for 15 minutes, then continue to decoct on low heat for 25 minutes, decoct 3 times, filter, combine the filtrate, and concentrate the filtrate to 50- The extract with a relative density of 1.20-1.25 at 60°C is mixed with 20% starch in the extract, pressed into tablets, and coated with a film to obtain tablets.

[0055] Specification: 0.5g / piece

[0056] Usage and dosage: 2-3 times a day, 2-3 tablets each time.

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Abstract

The invention discloses a medicine for treating chronic glomerulonephritis and nephrotic syndrome and a preparation method thereof. The medicine is mainly made of astragalus, dijincao, codonopsis, cornus, rehmannia glutinosa, atractylodes macrocephala, poria cocos and alisma alisma . The prepared medicine has the effects of invigorating the spleen and kidney, promoting yang and strengthening vital energy, diuresis and expelling dampness, can reduce proteinuria and hematuria, and treat chronic nephritis and nephrotic syndrome. It is suitable for the treatment of chronic nephritis, nephrotic syndrome proteinuria, and hematuria, and the TCM syndrome is spleen and kidney qi deficiency and damp turbidity.

Description

technical field [0001] The invention relates to a medicine for treating chronic glomerulonephritis and nephrotic syndrome and a preparation method thereof, belonging to the field of pharmaceutical technology. [0002] technical background [0003] Chronic glomerulonephritis (chronic nephritis for short) and nephrotic syndrome are damage to the protein filtration barrier system by glomerular capillaries, causing protein to be filtered out, resulting in proteinuria, hypoalbuminemia, edema, hyperlipidemia, etc. A syndrome of manifestations. The leakage of a large amount of proteinuria will cause hypoproteinemia, edema, low immunity, thrombosis, etc., and immune factors play a leading role in the occurrence of the disease. Therefore, reducing proteinuria and hematuria is the best way to treat chronic nephritis and nephrotic syndrome. Key points and difficulties. Traditional Chinese medicine believes that proteinuria and hematuria are the body's water and grain essence lost in u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K9/48A61K9/16A61K9/30A61K9/28A61P13/12
CPCA61K9/0095A61K9/1652A61K9/2806A61K9/282A61K36/076A61K36/284A61K36/344A61K36/40A61K36/47A61K36/481A61K36/804A61K36/884A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 李正胜谢娟张雄峰卢晶晶王叶黄海平王治义余慧娟
Owner 贵州中医药大学第二附属医院
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