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A kind of preparation method of pseudo-ginsenoside rg3, rh2, ppd

A technology for simulating ginsenosides and saponins is applied in the field of preparation of ginsenosides Rg3, Rh2 and PPD, which can solve the problems of aimlessness, low yield, complex components and the like, and achieves high targetability, low cost and easy availability. Effect

Inactive Publication Date: 2019-12-27
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Yin Jianyuan et al. used acid hydrolysis to obtain a ginsenoside PPD with a changed side chain (patent number: CN101054400A); rate is not high

Method used

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  • A kind of preparation method of pseudo-ginsenoside rg3, rh2, ppd
  • A kind of preparation method of pseudo-ginsenoside rg3, rh2, ppd
  • A kind of preparation method of pseudo-ginsenoside rg3, rh2, ppd

Examples

Experimental program
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Effect test

Embodiment 1

[0077] a. Acetylation preparation of protopanaxadiol group saponins: get 10g protopanaxadiol group saponins, dissolve in 90ml of acetic anhydride and 90ml of pyridine, heat and reflux in a constant temperature water bath at 40°C for 10 hours, evaporate under reduced pressure to remove solvent, and obtain protopanaxadiol 15.3 g of hissaponin acetylated product.

[0078] b. Preparation of the acetylated product of pseudoginsenoside Rg3 (acid-catalyzed degradation): take 10 g of the acetylated product of protopanaxadiol group saponin, dissolve it in 100 ml of glacial acetic acid, add 10 ml of 5% sulfuric acid, and react in a constant temperature bath at 4 °C for 20 hours , add sodium hydroxide solution to adjust the pH to 7.0, and recover the solvent to obtain the acetylated products of pseudoginsenoside Rg3 (type E and type Z), with a conversion rate of 57.6%. Acetylation of Pseudoginsenoside Rg3 1 H-NMR diagram see figure 1 ; Pseudoginsenoside Rg3 acetylation 13 C-NMR cha...

Embodiment 2

[0080] a. The acetylation preparation of protopanaxadiol saponins: get 10g protopanaxadiol saponins, add 100ml of acetic anhydride and 100ml of pyridine, heat and reflux in a constant temperature water bath at 30°C for 15 hours, evaporate under reduced pressure to remove solvent, and obtain protopanaxadiol group Saponin acetylation products.

[0081] b. Preparation of the acetylated product of pseudoginsenoside Rg3 (acid catalysis): take 10 g of the acetylated product of protopanaxadiol group saponin, dissolve it in 100 ml of glacial acetic acid, add 10 ml of 5% hydrochloric acid, and react in a constant temperature bath at 4 °C for 20 hours. Sodium hydroxide solution was added to adjust the pH to 7.0, and the solvent was recovered to obtain the acetylated products of pseudoginsenoside Rg3 (type E and type Z), with a conversion rate of 58.2%.

Embodiment 3

[0083] a. Acetylation preparation of protopanaxadiol saponins: get 10g protopanaxadiol saponins, add 80ml of acetic anhydride and 80ml of pyridine, heat and reflux in a constant temperature water bath at 25°C for 25 hours, evaporate under reduced pressure to remove solvent, and obtain protopanaxadiol group Saponin acetylation products.

[0084] b. Preparation of the acetylated product of pseudoginsenoside Rg3 (acid catalysis): take 10 g of the acetylated product of protopanaxadiol group saponin, dissolve it in 100 ml of acetic acid, add 10 ml of 5% hydrochloric acid, react in a constant temperature bath at 4 °C for 15 hours, add hydrogen Adjust the pH of the sodium oxide solution to 7.0, recover the solvent, and obtain the acetylated products of pseudoginsenoside Rg3 (type E and type Z), with a conversion rate of 56.8%.

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Abstract

The invention provides a preparation method of pseudo-ginsenosides Rg3, Rh2 and PPD. The method comprises the steps of by taking protopanaxadiol type saponin with lower cost as a starting raw material, enabling the acetylated protopanaxadiol type saponin to be subjected to an acid-catalyzed reaction at low temperature to obtain an acetylated pseudo-ginsenosides Rg3 product, and then enabling the acetylated pseudo-ginsenosides Rg3 product to be subjected to reactions under different alkaline conditions so as to respectively obtain the pseudo-ginsenosides Rg3, Rh2 and PPD. The method provided by the invention is a new preparation method, and is low in cost and easy to implement.

Description

technical field [0001] The invention discloses a method for preparing pseudo-ginsenosides Rg3, Rh2 and PPD from protopanaxadiol group saponins, using protopanaxadiol group saponins as raw materials to prepare pseudo-ginsenosides Rg3 (type E and type Z) and pseudo-ginsenosides The method of Rh2 (E-type and Z-type) and pseudo-ginsenoside PPD (E-type and Z-type), including acetylation preparation method, acid-catalyzed degradation preparation method, saponification preparation method, alkali degradation preparation method and purification steps, belongs to medicine Preparation technology field. Background technique [0002] Ginseng ( Panax ginseng C. A. Meyer) is derived from the rhizome of the Araliaceae plant ginseng, and enjoys the reputation of "the king of herbs" in China. A large number of scientific studies have shown that ginseng contains ginsenosides, ginseng polypeptides, ginseng polysaccharides, ginseng alcohols, ginseng proteins, etc., and ginsenosides are the sym...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J17/00C07J9/00
CPCC07J9/00C07J17/005
Inventor 陈燕萍王志才张朋飞徐芳菲许妍丁宏达钱广涛高威
Owner JILIN UNIV
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