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Biodegradable polymer

A biodegradable, polymer-based technology used in the construction of medical devices such as sutures to address physician error and inappropriate use of closure materials due to patient physiology

Active Publication Date: 2017-09-26
YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Three main factors contribute to the occurrence of POVH: (1) physician error, (2) patient physiology, and (3) inappropriate use of closure materials

Method used

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  • Biodegradable polymer
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Experimental program
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Embodiment Construction

[0320] Synthesis of polymers according to the invention

[0321] Generally, the synthesis of the polymers of the invention proceeds by first synthesizing the ABA tri-block or the AB di-block. In this general reaction, a pre-prepared poly(propylene oxide) B block (which can be purchased or synthesized from an initial diol and an excess of the appropriate epoxide, depending on the desired block length) is preferably combined with hydroxyl Acids or their cyclic lactones are reacted to produce low molecular weight ABA tri-blocks or AB di-blocks. Basically, poly(propylene oxide) generally terminated with a hydroxyl group or, in the case of an AB di-block, at one end with a hydroxyl group and at the other end with a non-reactive group The blocks are reacted with hydroxyacids or their cyclic lactones to produce ABA triblocks or AB diblocks comprising polypropylene and biodegradable components terminated with hydroxyl groups or other groups.

[0322] After the ABA triblock or AB d...

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Abstract

The invention provides a class of polymeric materials being ABA tri-block or AB di-block, comprised of biodegradable segments and poly(propylene oxide) (PPO) segment and uses thereof.

Description

technical field [0001] The present invention generally relates to a novel class of polymers and their use, for example in the construction of medical devices such as sutures. Background of the invention [0002] Up to 20% of patients who undergo abdominal wall opening surgery (Laparotomy) will develop a condition known as Post Operative Ventral Hernia (POVH) within 5 years. POVH means that when the bowel can become strangulated, the bowel normally contained within the abdominal wall breaks through this tissue, causing excruciating pain, disfigurement and even death. [0003] Normal healing of the abdominal wall is such that within two months of closure, the abdominal wall regains 80% of its original strength. Gold standard surgical sutures provide up to two months of tissue support. Three main factors contribute to the occurrence of POVH: (1) physician error, (2) patient physiology, and (3) inappropriate use of occlusive materials. The most important factor for POVH appea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/73C08G18/74C08G18/76C08G18/42C08G18/48C08G63/664C08G63/685C08G63/91A61L17/10A61L27/18
CPCA61L17/10A61L27/18C08G18/4277C08G18/4825C08G18/73C08G18/74C08G18/76C08G63/664C08G63/6852C08G63/912C08G2220/00C08G2230/00A61L27/34A61L31/06A61L31/10A61L15/26A61L17/12C08L67/04C08L71/02A61K47/34C08G18/42C08G63/685C08G63/91
Inventor D·科恩
Owner YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD