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Coding and decoding-based digital micro-fluidic biologic chip online test structure and method thereof

A digital microfluidic and biological chip technology, applied in electronic circuit testing, printed circuit testing, electrical measurement, etc., can solve the problems of untimely fault discovery, long error repair time, large chip size, etc., to reduce the use of pins , reduce the completion time, reduce the effect of testing cost

Active Publication Date: 2017-10-10
HARBIN INST OF TECH AT WEIHAI
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Problems solved by technology

[0009] The present invention aims at the technical problems of untimely fault discovery, long error repair time, high resource consumption, and excessive chip scale caused by too many control pins in the existing digital microfluidic biochip online test, and provides a timely fault detection method. Structure and method for on-line testing of digital microfluidic biochips based on coding and decoding with short repair time, low resource consumption, and few pin introductions

Method used

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  • Coding and decoding-based digital micro-fluidic biologic chip online test structure and method thereof
  • Coding and decoding-based digital micro-fluidic biologic chip online test structure and method thereof
  • Coding and decoding-based digital micro-fluidic biologic chip online test structure and method thereof

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Embodiment Construction

[0024] The present invention will be further described below in conjunction with the examples.

[0025] Such as figure 1 As shown, the I / O interface of the digital microfluidic biochip includes a latch, a 4-wire-2-wire encoder group and a 2-wire-4-wire decoder group, and the latch, 2-wire-4-wire decoder group The controller group, electrode sequence and 4-wire encoder group are sequentially connected, the controller is connected with the latch and the 4-wire-2-wire encoder group through the data bus, and the time-division multiplexing of input and output signals is realized through the latch .

[0026] Such as image 3 As shown, each output terminal of the 2-wire-4-wire decoder corresponds to an electrode, and each electrode is connected to the input terminal of the 4-wire-2-wire encoder at the same time. That is, the number of 4-wire-2-wire encoder and 2-wire-4-wire decoder is the same, and it is a quarter of the number of electrodes.

[0027] The test process is mainly d...

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Abstract

The present invention provides a coding and decoding-based digital micro-fluidic biologic chip online test structure and a method thereof. The invention solves the technical problems in the prior art that the during the online test process, faults cannot be timely found and are long in repair time and large in resource consumption, and chips are too large in size due to the arrangement of multiple control pins. The structure comprises a decoder, a controller and an encoder. The input end of the decoder is connected with the controller, and the output end of the decoder is connected with an electrode. The decoder is used for converting a voltage signal into an electrode driving sequence according to a coding rule and applying the electrode driving sequence to each electrode. The input end of the encoder is connected with the electrode, and the output end of the encoder is connected with the controller. The encoder is used for transmitting the actual voltage signal of each electrode back to the controller through a data bus after the circuit coding process. The controller is used for comparing the transmitted voltage signal with an output voltage signal, and judging whether the electrode has a fault or not. If yes, the corresponding electrode is marked as faulty. After that, the subsequent droplet scheduling is adjusted. The structure and the method are widely applied to the online test technical field of digital micro-fluidic biologic chips.

Description

technical field [0001] The invention relates to the technical field of on-line testing of digital microfluidic biochips, in particular to an on-line testing structure and method for digital microfluidic biochips based on coding and decoding. Background technique [0002] The digital microfluidic biochip is mainly composed of a two-dimensional electrode array. The upper plate is a large electrode covering all the units in the array, which serves as a common ground; the lower plate applies different control voltages according to the needs during use. Please refer to Document 1 (R. Fair, A. Khlystov, V. Srinivasan, V. Pamula, and K. Weaver, "Integrated chemical / biochemical sample collection, pre-concentration, and analysis on digital microfluidic lab-on-a-chip platform", Proceedings of SPIE, volume 5591, Issue 8, pages 113–124, 2004). Based on the dielectric wetting technology, the nanoliter droplet is confined between the two plates during operation. By applying a low level t...

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Application Information

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IPC IPC(8): G01R31/28
CPCG01R31/281G01R31/282G01R31/2851
Inventor 邓立宝孙宁任涛张莉莉王华鹏周长波
Owner HARBIN INST OF TECH AT WEIHAI
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