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Application of dicliptera chinensis polysaccharide in preparing radioactive xerostomia medicine

A dog liver vegetable and radioactive technology, applied in the field of medicine, can solve the problems of unanalyzed monosaccharide components and structures, and achieve the effect of overcoming the inertia and limitations of research thinking, easy availability of raw materials, and high content

Active Publication Date: 2017-10-24
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, in the prior art, only dog ​​liver vegetable polysaccharide (DCP1A) has been prepared, and its monosaccharide composition and structure have not been analyzed

Method used

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  • Application of dicliptera chinensis polysaccharide in preparing radioactive xerostomia medicine
  • Application of dicliptera chinensis polysaccharide in preparing radioactive xerostomia medicine
  • Application of dicliptera chinensis polysaccharide in preparing radioactive xerostomia medicine

Examples

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Effect test

Embodiment 1

[0030] 1 Separation and extraction of dog liver vegetable polysaccharide

[0031] Weigh 2.00kg of dried dog liver vegetable and cut it into a size of about 2cm, add 8L of distilled water, extract at 90°C for 4 hours, repeat 3 times, combine the extracts, concentrate in a rotary evaporator at 65°C to 200ml, and then slowly pour into anhydrous In ethanol (V concentrated solution: V absolute ethanol = 1:4), after shaking sufficiently, let it stand overnight, collect the alcohol precipitate the next day, freeze-dry it in a vacuum freeze dryer, and collect the crude polysaccharide of dog liver vegetable for use.

[0032] 1.2 Separation and extraction of crude polysaccharides from dog liver dish

[0033] 1.2.1 Dog liver vegetable crude polysaccharide deproteinization

[0034] Take the crude polysaccharide of dog liver vegetable after freeze-drying, add distilled water to make the final concentration 5.00% (g / mL), add papain to make the final concentration 1.00% (g / mL), after fully ...

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Abstract

The invention relates to the technical field of medicines, in particular to application of dicliptera chinensis polysaccharide in preparing radioactive xerostomia medicines. According to the application disclosed by the invention, animal experiments show that the dicliptera chinensis polysaccharide is suitable for preventing and treating radioactive xerostomia and has accurate curative effect and good pharmaceutical value in preparing medicines or health-care products for preventing and treating the radioactive xerostomia. Furthermore, a preparation technology for the dicliptera chinensis polysaccharide is simple, raw materials for preparing the dicliptera chinensis polysaccharide are easy to obtain, and preparation cost is further reduced. In addition, the dicliptera chinensis polysaccharide has high yield, high content, no any toxic or side effect, good taste and good development value.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine, in particular to the application of dog liver vegetable polysaccharide in preparing radioactive xerostomia medicine. 【Background technique】 [0002] At present, radiation therapy is still one of the treatment methods for malignant tumors of the head and neck. However, due to the location of the salivary gland and its high sensitivity to radiation, the malignant tumor cells are killed and the adjacent salivary gland tissue is also damaged. , causing many complications of salivary glands, among which radiation xerostomia seriously affects the quality of life of patients. Therefore, research on the prevention and treatment of salivary gland radiation xerostomia has always been a focus of attention of scholars at home and abroad. [0003] Dicliptera chinensis L.Ness is mainly produced in Guangdong, Guangxi and other southern regions of my country. It has the functions of clearing heat and detoxify...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P1/00A61P5/00
CPCA61K31/715A61K36/19
Inventor 王代友孙喆张岩
Owner GUANGXI MEDICAL UNIVERSITY
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