Modular cell culture and transportation assembly

A cell culture and modular technology, applied in the field of biological devices, can solve the problems of different technical and operational levels, difficulty in unifying and improving the quality and effect of cell therapy, and limiting the promotion and application of cell therapy technology, etc., to achieve a solution Effect of cell contamination, reduction of risk of cell contamination, solution to transport issues

Inactive Publication Date: 2017-10-24
JIANGSU JIANAN BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This limits the promotion and application of cell therapy technology
At the same time, due to the different technical and operational levels of the staff of each hospital or research institute, it is also difficult to unify and improve the quality and effect of cell therapy

Method used

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  • Modular cell culture and transportation assembly
  • Modular cell culture and transportation assembly
  • Modular cell culture and transportation assembly

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] see Figure 1 to Figure 4 , a modular cell culture and transport assembly according to a preferred embodiment of the present invention, comprising a top cover 1, a connection frame 2 positioned below the top cover, a bottom cover 3 positioned below the connection frame, and the top cover is a box with the opening downward The connection frame is a rectangular frame body, the bottom cover is a box-like structure with an opening upward, a breathable film 4 is arranged between the top cover and the connection frame, and the edge of the breathable film is fixedly arranged on the inner side of the top cover. A water-permeable membrane 5 is arranged between the bottom covers, and the edge of the water-permeable membrane is fixedly arranged on the inner side of the bottom cover. A cell culture chamber 7 for culturing cells, surrounded by a water-permeable membrane and a bottom cover to form a culture medium chamber 8 for storing culture fluid, the side wall of the top cover is...

Embodiment 2

[0048] see Figure 5 and Figure 6 , the structure of this embodiment is basically the same as that of the modular cell culture and transport assembly in Embodiment 1, slots are respectively provided on the upper surface and the lower surface of the connection frame, and slots are respectively provided on the lower surface of the top cover and the upper surface of the bottom cover. There is a positioning plate 17 adapted to the slot. The left and right sides of the bottom cover are respectively provided with connecting plates 18, the bottom ends of the connecting plates are hinged on the outer surfaces of the bottom cover, and the top ends of the connecting plates are detachably connected with the top cover. A positioning groove 19 is provided on the outer surface of the top cover, and a locking bolt 20 threadedly connected with the positioning groove is provided on the connecting plate. A first handle 21 is hinged on the outer surface of the connecting plate. A second hand...

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Abstract

The invention relates to a modular cell culture and transportation assembly comprises a top cover, a connecting frame located below the top cover and a bottom cover located below the connecting frame. An air-permeable membrane is arranged between the top cover and the connecting frame, a water-permeable membrane is arranged between the connecting frame and the bottom cover, the top cover and the air-permeable membrane form an air chamber for storing air through surrounding, the air-permeable membrane, the connecting frame and the water-permeable membrane form a cell culture chamber for cell culture through surrounding, the water-permeable membrane and the bottom cover form a culture medium chamber for storing a culture solution through surrounding, an air inlet and an air outlet communicated with the air chamber are respectively formed in the side wall of the top cover, a cell inlet and a cell outlet respectively communicated with the cell culture chamber are formed in the side wall of the connecting frame, a culture medium inlet and a culture medium outlet communicated with the culture medium chamber are formed in the side wall of the bottom cover, and a pH value sensor is also arranged in the culture medium chamber. The modular cell culture and transportation assembly is high in automatic degree, lower in cost, safe and effect, makes cell culture convenient and makes transportation convenient.

Description

technical field [0001] The invention relates to a biological device, in particular to a cell modular culture and transport assembly. Background technique [0002] With the widespread use of stem cells and immune cells in medical treatment, standardized, personalized and large-scale cell production and transportation have become one of the key bottlenecks in the development and application of the medical field. The National Cell Manufacturing Consortium (NCMC) of the United States pointed out in its 10-year roadmap for large-scale production of various cells for clinical treatment published in early 2016 that in the current industrialized cell production process, starting from the cell production process , storage, distribution, processing and other steps have a series of areas to be improved and standardized in technology, monitoring, data management and so on. And this production process is further complicated by the need for treatment individualization. [0003] There ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M1/34C12M1/04C12M1/00
CPCC12M29/00C12M37/04C12M41/12C12M41/26
Inventor 王建新郝晓勇顾云
Owner JIANGSU JIANAN BIOLOGICAL TECH
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