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A kind of psoralen polymer nanoparticle preparation with high encapsulation efficiency and preparation method thereof

A psoralen and nanoparticle technology, applied in the directions of active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, drug combinations, etc., can solve the problems of poor stability and low encapsulation rate of PLN preparations, and achieve stability. Good, improve the effect of encapsulation rate and stability

Active Publication Date: 2020-06-26
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the problems of low encapsulation efficiency and poor stability of the existing PLN preparations with psoralen as the active drug, the present invention provides a preparation that obtains higher encapsulation efficiency and better stability by optimizing components and preparation conditions. Psoralen polymer nanoparticle preparation, and preparation method of this kind of psoralen polymer nanoparticle preparation

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  • A kind of psoralen polymer nanoparticle preparation with high encapsulation efficiency and preparation method thereof
  • A kind of psoralen polymer nanoparticle preparation with high encapsulation efficiency and preparation method thereof
  • A kind of psoralen polymer nanoparticle preparation with high encapsulation efficiency and preparation method thereof

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Embodiment 1-86

[0031] The preparation method of the psoralen polymer nanoparticle preparation provided by embodiment 1-86, the specific steps are as follows (consumption and process parameters of each material in each embodiment are as shown in Table 1 and Table 2):

[0032] (1) Material collection: Weigh psoralen, polylactide-glycolide, soybean lecithin and Tween-80 according to the amount of each component, and set aside.

[0033] (2) Preparation of organic phase: dissolving polylactide-glycolide in an organic solvent, then adding psoralen into the organic solvent to form an organic phase; set aside.

[0034] (3) Preparation of water phase: dissolving soybean lecithin and Tween-80 in aqueous ethanol solution to form water phase for later use.

[0035] (4) Emulsion preparation: uniformly inject the organic phase into the water phase with a syringe to form a mixed solution; heat the mixed solution to 60-80°C and stir the mixed solution at a speed of 10-30rmp for 30-120min to form an emulsion...

Embodiment 87

[0050] The preparation method of the psoralen polymer nanoparticle preparation provided in this embodiment is basically the same as that in Example 4, except that:

[0051] Step (1) taking material is: take by weighing respectively 3mg psoralen, 15mg polylactide-glycolide (same as that of embodiment 4), 42mg soybean lecithin, 8mg synthetic phospholipid (DLPC) and 500mg Tween-80 ,spare.

[0052] Step (3) preparing the water phase is: dissolving soybean phospholipids, synthetic phospholipids and Tween-80 in 20 mL of 4wt.% ethanol aqueous solution to form a water phase for later use.

Embodiment 88

[0054] The preparation method of the psoralen polymer nanoparticle preparation provided in this embodiment is basically the same as that in Example 4, except that:

[0055] Step (1) taking material is: take by weighing 3mg psoralen, 15mg polylactide-glycolide (identical with embodiment 4), 50mg synthetic phospholipid (DLPC) and 500mg dimethylaminoborane ( DMAB), spare.

[0056] Step (3) to prepare the water phase: dissolve the synthetic phospholipid and dimethylaminoborane in 20 mL of 4wt.% ethanol aqueous solution to form the water phase for later use.

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Abstract

The invention relates to the technical field of polymer nanoparticle preparations and particularly relates to a psoralen polymer nanoparticle preparation with a high encapsulation rate and a preparation method of the nanoparticle preparation. According to the preparation method, a proper amount of psoralen, polylactide-glycolide, granulesten and Tween 80 are taken as the raw materials, particularly Tween 80 is taken as a surfactant, granulesten is taken as a lipid, and the psoralen polymer nanoparticle preparation with relatively high encapsulation rate and stability can be prepared. By optimizing preparation conditions of the psoralen polymer nanoparticle preparation, the encapsulation rate and stability of the psoralen polymer nanoparticle preparation can be further increased, the encapsulation rate can reach up to 82.45%, and the particle size is about 100m; and after standing at 4 DEG C for 3 days, no white precipitate is generated, and the stability of the preparation is good.

Description

technical field [0001] The invention relates to the technical field of polymer nanoparticle preparations, in particular to a psoralen polymer nanoparticle preparation with high encapsulation efficiency and a preparation method thereof. Background technique [0002] Tumor is one of the major diseases that endanger human health today. Tumor invasion and metastasis are the most common biological behavior and the most essential characteristics of malignant tumors, and they are also key factors affecting the survival and prognosis of cancer patients. Therefore, antitumor drugs are a subject of continuous research and development by those skilled in the art. In recent years, people have turned to other approaches to find effective ways to reverse the MDR of tumor cells. Due to the small size and special structure of nanoparticles, they show unique advantages in improving drug absorption, distribution, metabolism, excretion, and toxicity. Therefore, nano drug delivery systems and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K31/37A61K47/26A61K47/24A61K47/34A61P35/00A61P35/04
CPCA61K9/5123A61K9/5153A61K31/37
Inventor 蔡宇袁月玲李倩文张荣华杨丽黄青青王冰月
Owner JINAN UNIVERSITY