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The application of bisidococcal live bacterial capsules and its application in preparing premature ovarian aging drugs

A technology for bifidobacteria and premature ovarian failure, applied in the field of biopharmaceuticals, can solve problems such as side effects, POF is not recommended, and there is no clear immunotherapy medication plan.

Active Publication Date: 2018-08-28
HARBIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no clear method to identify the role of immune factors in POF, and there is no clear indication and standardized drug regimen for immunotherapy, and immunosuppressive therapy can cause serious side effects, so blind application is not recommended clinically Immunosuppressant therapy for POF

Method used

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  • The application of bisidococcal live bacterial capsules and its application in preparing premature ovarian aging drugs
  • The application of bisidococcal live bacterial capsules and its application in preparing premature ovarian aging drugs
  • The application of bisidococcal live bacterial capsules and its application in preparing premature ovarian aging drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Experimental research on the prevention of premature ovarian failure by bifidobacterium live bacteria capsules

[0052] 1 material

[0053] 1.1 Animals

[0054] Female Wistar mice aged 10-12 weeks, weighing 18-22 g, were provided by the Animal Center of Heilongjiang University of Traditional Chinese Medicine. Animal certificate number: Yidongzi No. 1024-03. The experimental animals were fed for 24 hours in advance to adapt to the laboratory feeding conditions.

[0055] 1.2 Drugs and reagents

[0056] Live Bifidobacterium Capsules, produced by Livzon Pharmaceutical Factory of Livzon Group, approved by S10960040. Pig egg zona pellucida (PZP) was prepared by Shenyang Family Planning Research Institute. Freund's complete adjuvant and Freund's incomplete adjuvant (IFA), produced by Shanghai Yuanye Biotechnology Co., Ltd.; estradiol (E 2 ) radioimmunotherapy kit, produced by Tianjin Jiuding Medical Bioengineering Co., Ltd.; goat anti-mouse-labeled horseradish...

Embodiment 2

[0099] Example 2: Experimental research on the treatment of ovarian cysts with bifidobacterium live bacteria capsules

[0100] 1 material

[0101] 1.1 Test animals

[0102] 48 healthy adult female Wistar rats of SPF grade, two months old, weighing (200±10) g, were provided by the Animal Center of Heilongjiang University of Traditional Chinese Medicine. Animal certificate number: Yidongzi No. 1024-03. The experimental animals were fed for 24 hours in advance to adapt to the laboratory feeding conditions.

[0103] 1.2 Drugs and preparation

[0104] Live Bifidobacterium Capsules, produced by Livzon Pharmaceutical Factory of Livzon Group, approved by S10960040. Make every milliliter to contain the liquid medicine of 1g, put in refrigerator 4 ℃ and preserve.

[0105] Positive control drug: Guizhi Fuling Capsule: produced by Jiangsu Kangyuan Pharmaceutical Co., Ltd., made into a medicinal solution containing 1g per milliliter, and stored in a refrigerator at 4°C.

[0106] 1.3 ...

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Abstract

The invention relates to the technical field of biological medicines, provides a live bifidobacterium capsule and applications of the live bifidobacterium capsule in preparing medicines for preventing premature ovarian failure, and relates to the live bifidobacterium capsule and applications of the live bifidobacterium capsule in preparing the medicines for preventing premature ovarian failure. With the technology provided by the invention, the clinical applications of the live bifidobacterium capsule are expanded, and meanwhile, a novel medication choice and a novel clinical diagnosis and treatment scheme are provided for preventing premature ovarian failure.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to a live bifidobacterium capsule and its new pharmaceutical application. Background technique [0002] Premature ovarian failure (POF) refers to the phenomenon of amenorrhea before the age of 40 caused by ovarian failure. It is characterized by primary or secondary amenorrhea accompanied by elevated blood gonadotropin levels and decreased estrogen levels, accompanied by a series of low estrogen symptoms such as hot flashes, hyperhidrosis, facial flushing, and low libido. The average natural menopausal age of women is 50-52 years old, and there are differences in the distribution of menopausal age among races and regions, but the absolute value is not much different. The incidence of POF was 1% for those younger than 40 years old, and 1‰ for those younger than 30 years old. POF accounts for 10% to 28% in primary amenorrhea, and 4% to 18% in secondary amenorrhea. Xu Lin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/745A61K9/48A61P15/08A61P35/00A61P1/00A61P1/06
CPCA61K9/48A61K35/745
Inventor 王淑梅焦月华胡宝忠孟令波
Owner HARBIN UNIV
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