Probiotic bifidobacterium strain

A technology of bifidobacteria and strains, applied in bacteria, antibacterial drugs, antifungal agents, etc., can solve problems such as host injury
CN102946891AActive Publication Date: 2013-02-27PRECISIONBIOTICS GRP LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PRECISIONBIOTICS GRP LTD
Publication Date
2013-02-27

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Abstract

Probiotic Bifidobacterium strain AH1714 is significantly immunomodulatory following oral consumption. The strain is useful as an immunomodulatory biotherapeutic agent.
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Description

Background of the invention

[0001] The present invention relates to bifidobacterium strains and their use as probiotics, in particular as immunoregulatory biotherapeutics.

[0002] The defense mechanisms that protect the human gastrointestinal tract from colonization with enteric bacteria are highly complex and involve both immune and non-immune aspects (1). Innate defense mechanisms include low pH of the stomach, bile salts, motility, mucin layer and antimicrobial compounds such as lysozyme (2). The immunological mechanism involves specific lymphoid aggregates beneath M cells, called Peyers patches, which are distributed throughout the small intestine and colon (3). Luminal antigens present at these locations stimulate appropriate T and B cell subsets, establish cytokine networks and secrete antibodies into the gastrointestinal tract (4). In addition, antigens can be presented via epithelial cells to intraepithelial lymphocytes and underlying lamina propria immune cells (5)...

Claims

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