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Protein, enzyme, metabolite, nucleic acid, microorganism etc that has therapeutic characteristics; originated as a biological product but may be engineered to produce optimal therapeutic value; may include synthetic mimics.
A specific recognition antigen epitope 16 AQTGYAPV 23 Monoclonal antibody D3-mAb against porcine rotavirus and its application
PendingCN122080190APreserve the original structureEpitope conservationImmunoglobulins against virusesAntiviralsAntigen epitopeAntigen
This invention discloses a method for specifically recognizing antigen epitopes. 16 AQTGYAPV 23 This invention relates to a monoclonal antibody D3-mAb against porcine rotavirus and its applications, belonging to the field of antibody bioengineering technology. The monoclonal antibody D3-mAb specifically binds to the VP8 protein of porcine rotavirus and exhibits neutralizing activity; its amino acid sequence is shown in SEQ ID NO. 8. This invention screened a monoclonal antibody D3 with neutralizing activity against the VP8 protein, and subsequently identified the neutralizing antigenic epitope. 16 AQTGYAPV 23 Recognized by D3-mAb, sequence comparison analysis of currently circulating PoRVA strains revealed that this antigenic epitope is absolutely conserved. Furthermore... 16 AQTGYAPV 23 The epitope, located on the surface of the VP8 protein, interacts with the antibody's variable region via six hydrogen bonds. This invention provides a novel approach for designing novel epitope vaccines and antiviral strategies, and the provided monoclonal antibody holds promise for development into a biotherapeutic agent and diagnostic agent for porcine rotavirus infection.
Owner:HEBEI AGRICULTURAL UNIV.